Synpo2 MGI Mouse Gene Detail - MGI:2153070

Symbol

Synpo2
Name

synaptopodin 2
Synonyms

1110069I04Rik, 2310068J10Rik, 9530006G20Rik, Myo, myopodin

Feature Type

protein coding gene
IDs

MGI:2153070
NCBI Gene: 118449
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr3:122870168-123029798 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 53.80 cM, cytoband G3
Mapping Data

3 experiments

SNPs within 2kb

5083 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2153070	protein coding gene	Chr3:122870168-123029817 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027847	protein coding gene	Chr3:125388553-125549502 (-)
A/J	MGP_AJ_G0027806	protein coding gene	Chr3:121180820-121335790 (-)
AKR/J	MGP_AKRJ_G0027771	protein coding gene	Chr3:124272265-124434076 (-)
BALB/cJ	MGP_BALBcJ_G0027818	protein coding gene	Chr3:120993882-121147789 (-)
C3H/HeJ	MGP_C3HHeJ_G0027548	protein coding gene	Chr3:124669785-124831036 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028263	protein coding gene	Chr3:129915290-130086867 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025600	protein coding gene	Chr3:116604588-116755532 (-)
CAST/EiJ	MGP_CASTEiJ_G0027003	protein coding gene	Chr3:124071009-124238113 (-)
CBA/J	MGP_CBAJ_G0027523	protein coding gene	Chr3:134314748-134478906 (-)
DBA/2J	MGP_DBA2J_G0027664	protein coding gene	Chr3:120308657-120464146 (-)
FVB/NJ	MGP_FVBNJ_G0027632	protein coding gene	Chr3:117927308-118087290 (-)
LP/J	MGP_LPJ_G0027774	protein coding gene	Chr3:126890165-127069679 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027662	protein coding gene	Chr3:141887121-142056570 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028319	protein coding gene	Chr3:123831249-123990143 (-)
PWK/PhJ	MGP_PWKPhJ_G0026729	protein coding gene	Chr3:120042363-120201916 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026553	protein coding gene	Chr3:121939028-122100524 (-)
WSB/EiJ	MGP_WSBEiJ_G0027083	protein coding gene	Chr3:124574622-124734519 (-)

Human Ortholog

SYNPO2, synaptopodin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYNPO2, synaptopodin 2
Synonyms

SYISL
Links

HGNC:17732

NCBI Gene ID: 171024

neXtProt AC: NX_Q9UMS6

UniProt: Q9UMS6
Chr Location

4q26; chr4:118850681-119061247 (+) GRCh38

MGI Vertebrate Homology

Synpo2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYNPO2
Gene Tree

Synpo2

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Synpo2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

37
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

45
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN synpo2b

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All Sequences

59
RefSeq

10
UniProt

7
CCDS

CCDS51063.1

Ensembl

ENSMUSG00000050315 (Evidence)
NCBI Gene

118449

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050315	Ensembl Gene Model \| MGI Sequence Detail	159631	C57BL/6J	± kb
transcript	ENSMUST00000106426	Ensembl \| MGI Sequence Detail	7063	Not Applicable
polypeptide	ENSMUSP00000102034	Ensembl \| MGI Sequence Detail	1257	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000015887 synaptopodin-2

(term hierarchy)
InterPro Domains

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR051976 Synaptopodin domain-containing protein
GlyGen

Q91YE8 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)

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All nucleic 8

cDNA 7

Other 1

Microarray probesets 7

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MGI:1916137, MGI:1922069, MGI:2139816, MGI:2443851

Summaries

All 43

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Synpo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35498	Chr3:123029783-123029806 (-)	3 bp
Tssr35497	Chr3:123029760-123029771 (-)	32 bp
Tssr35496	Chr3:123018782-123018786 (-)	11,014 bp
Tssr35495	Chr3:122910906-122910915 (-)	118,887 bp
Tssr35494	Chr3:122910844-122910847 (-)	118,952 bp
Tssr35493	Chr3:122910813-122910818 (-)	118,982 bp
Tssr35492	Chr3:122910662-122910700 (-)	119,117 bp
Tssr35491	Chr3:122910634-122910645 (-)	119,158 bp
Tssr35490	Chr3:122908122-122908144 (-)	121,665 bp
Tssr35489	Chr3:122907995-122908032 (-)	121,784 bp
Tssr35488	Chr3:122907887-122907904 (-)	121,902 bp
Tssr35487	Chr3:122907410-122907440 (-)	122,373 bp
Tssr35486	Chr3:122907216-122907227 (-)	122,576 bp
Tssr35485	Chr3:122906539-122906553 (-)	123,252 bp
Tssr35484	Chr3:122898931-122898934 (-)	130,865 bp
Tssr35483	Chr3:122879575-122879596 (-)	150,212 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24