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Hnmt Gene Detail
Summary
  • Symbol
    Hnmt
  • Name
    histamine N-methyltransferase
  • Synonyms
    1500031F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153181
    NCBI Gene: 140483
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:23892922-23939406 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1208 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153181
 protein coding gene Chr2:23892922-23939756 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025401
 protein coding gene Chr2:21779431-21827721 (-)
A/J MGP_AJ_G0025379
 protein coding gene Chr2:20936087-20982482 (-)
AKR/J MGP_AKRJ_G0025348
 protein coding gene Chr2:21629068-21681247 (-)
BALB/cJ MGP_BALBcJ_G0025374
 protein coding gene Chr2:21040733-21090626 (-)
C3H/HeJ MGP_C3HHeJ_G0025135
 protein coding gene Chr2:21582426-21631099 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025818
 protein coding gene Chr2:22447831-22496543 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023230
 protein coding gene Chr2:19894052-19935248 (-)
CAST/EiJ MGP_CASTEiJ_G0024598
 protein coding gene Chr2:21454269-21497679 (-)
CBA/J MGP_CBAJ_G0025113
 protein coding gene Chr2:23283670-23339649 (-)
DBA/2J MGP_DBA2J_G0025246
 protein coding gene Chr2:20817608-20861366 (-)
FVB/NJ MGP_FVBNJ_G0025208
 protein coding gene Chr2:20543713-20589545 (-)
LP/J MGP_LPJ_G0025332
 protein coding gene Chr2:21709597-21757196 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025239
 protein coding gene Chr2:23455403-23505709 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025877
 protein coding gene Chr2:21575168-21621235 (-)
PWK/PhJ MGP_PWKPhJ_G0024347
 protein coding gene Chr2:20600186-20649666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024147
 protein coding gene Chr2:21675208-21719906 (-)
WSB/EiJ MGP_WSBEiJ_G0024668
 protein coding gene Chr2:21669005-21708524 (-)



Homology
more
  • Human Ortholog
    HNMT, histamine N-methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNMT, histamine N-methyltransferase
  • Synonyms
    HMT, HNMT-S1, HNMT-S2, MRT51
  • Links
    NCBI Gene ID: 3176
    neXtProt AC: NX_P50135
    UniProt: P50135

  • Chr Location
    2q22.1; chr2:137964020-138016364 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human HNMT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit elevated histamine levels in the brain, increased aggression, hypoactivity and altered sleep-wake cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    22
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026986 Ensembl Gene Model | MGI Sequence Detail 46485 C57BL/6J ±  kb
transcript ENSMUST00000114497 Ensembl | MGI Sequence Detail 994 Not Applicable  
polypeptide ENSMUSP00000110141 Ensembl | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008656 histamine N-methyltransferase
    (term hierarchy)
  • EC
    2.1.1.8
  • InterPro Domains
    IPR016673 Histamine N-methyltransferase-like
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
  • GlyGen
    Q91VF2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923597, MGI:2139051
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:350837 McClain JL, et al., Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity. Biomolecules. 2023 Nov 14;13(11)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory