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Kcnn3 Gene Detail
Summary
  • Symbol
    Kcnn3
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
  • Synonyms
    SK3, small conductance calcium-activated potassium channel 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153183
    NCBI Gene: 140493
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89427471-89579801 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.16 cM, cytoband F2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3790 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153183
 protein coding gene Chr3:89427471-89582439 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027443
 protein coding gene Chr3:89745769-89904051 (+)
A/J MGP_AJ_G0027407
 protein coding gene Chr3:86770795-86927891 (+)
AKR/J MGP_AKRJ_G0027371
 protein coding gene Chr3:88873026-89028136 (+)
BALB/cJ MGP_BALBcJ_G0027416
 protein coding gene Chr3:86741936-86897382 (+)
C3H/HeJ MGP_C3HHeJ_G0027158
 protein coding gene Chr3:89077451-89235599 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027862
 protein coding gene Chr3:93134663-93293138 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025214
 protein coding gene Chr3:82252465-82412259 (+)
CAST/EiJ MGP_CASTEiJ_G0026604
 protein coding gene Chr3:89433539-89604979 (+)
CBA/J MGP_CBAJ_G0027132
 protein coding gene Chr3:96339156-96499346 (+)
DBA/2J MGP_DBA2J_G0027270
 protein coding gene Chr3:86148027-86303741 (+)
FVB/NJ MGP_FVBNJ_G0027238
 protein coding gene Chr3:84489038-84642947 (+)
LP/J MGP_LPJ_G0027379
 protein coding gene Chr3:90820467-90978783 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027258
 protein coding gene Chr3:102525981-102688107 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027921
 protein coding gene Chr3:88626436-88784283 (+)
PWK/PhJ MGP_PWKPhJ_G0026338
 protein coding gene Chr3:86030265-86189196 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026157
 protein coding gene Chr3:87807083-87969969 (+)
WSB/EiJ MGP_WSBEiJ_G0026686
 protein coding gene Chr3:89020597-89183279 (+)



Homology
more
  • Human Ortholog
    KCNN3, potassium calcium-activated channel subfamily N member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNN3, potassium calcium-activated channel subfamily N member 3
  • Synonyms
    hSK3, KCa2.3, SK3, SKCA3, ZLS3
  • Links
    NCBI Gene ID: 3782
    neXtProt AC: NX_Q9UGI6
    UniProt: Q9UGI6

  • Chr Location
    1q21.3; chr1:154697455-154870281 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNN3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an insertion of a tetracycline-regulated gene switch display no overt phenotype when expression is abolished by doxycycline treatment; in contrast, untreated homozygotes show abnormal respiratory responses to hypoxia, impaired parturition, and pregnancy-related premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    18
  • cDNA Data
    16
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 140493 NCBI Gene Model | MGI Sequence Detail 152331 C57BL/6J ±  kb
transcript NM_080466 RefSeq | MGI Sequence Detail 7617 C57BL/6  
polypeptide P58391 UniProt | EBI | MGI Sequence Detail 732 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000714 small conductance calcium-activated potassium channel protein 3
    (term hierarchy)
  • InterPro Domains
    IPR004178 Calmodulin-binding domain
    IPR015449 Potassium channel, calcium-activated, SK
    IPR013099 Potassium channel domain
    IPR036122 SK, calmodulin-binding domain superfamily
  • GlyGen
    P58391 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 19
    cDNA 16
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 77
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 6
    Phenotypes 38
  • Earliest
    J:95064 Bond CT, et al., Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Science. 2000 Sep 15;289(5486):1942-6
  • Latest
    J:352295 Ye H, et al., 27-Hydroxycholesterol acts on estrogen receptor alpha expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior. Sci Adv. 2024 Jul 12;10(28):eadi4746
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory