Cd300c2 MGI Mouse Gene Detail - MGI:2153249

Symbol

Cd300c2
Name

CD300C molecule 2
Synonyms

AF251705, Cd300d, Clm4, DIgR1, Igsf7, LMIR2, MAIR-II

Feature Type

protein coding gene
IDs

MGI:2153249
NCBI Gene: 140497
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:114887595-114892706 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.57 cM
Mapping Data

2 experiments

SNPs within 2kb

336 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2153249	protein coding gene	Chr11:114887547-114895058 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019368	protein coding gene	Chr11:118975500-118982469 (-)
A/J	MGP_AJ_G0019336	protein coding gene	Chr11:113790171-113796731 (-)
AKR/J	MGP_AKRJ_G0019304	protein coding gene	Chr11:117173102-117189062 (-)
BALB/cJ	MGP_BALBcJ_G0019311	protein coding gene	Chr11:114199702-114207309 (-)
C3H/HeJ	MGP_C3HHeJ_G0019118	protein coding gene	Chr11:117527912-117533132 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019760	protein coding gene	Chr11:122537019-122542900 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017380	protein coding gene	Chr11:110743855-110747898 (+)
CAST/EiJ	MGP_CASTEiJ_G0018672	protein coding gene	Chr11:118848257-118856710 (-)
CBA/J	MGP_CBAJ_G0019088	protein coding gene	Chr11:127461202-127466404 (-)
DBA/2J	MGP_DBA2J_G0019200	protein coding gene	Chr11:113223262-113235685 (-)
FVB/NJ	MGP_FVBNJ_G0019191	protein coding gene	Chr11:112736980-112741716 (-)
LP/J	MGP_LPJ_G0019271	protein coding gene	Chr11:119373010-119378539 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019223	protein coding gene	Chr11:126597156-126619883 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019797	protein coding gene	Chr11:117835826-117843315 (-)
PWK/PhJ	MGP_PWKPhJ_G0018437	protein coding gene	Chr11:114532065-114537555 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018228	protein coding gene	Chr11:117638682-117643368 (-)
WSB/EiJ	MGP_WSBEiJ_G0018725	protein coding gene	Chr11:117789005-117799244 (-)

Human Ortholog

CD300C, CD300c molecule

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD300C, CD300c molecule
Synonyms

CLM-6, CMRF-35, CMRF35, CMRF-35A, CMRF35A, CMRF35-A1, CMRF35A1, IGSF16, LIR
Links

HGNC:19320

NCBI Gene ID: 10871

neXtProt AC: NX_Q08708

UniProt: Q08708
Chr Location

17q25.1; chr17:74534635-74546115 (-) GRCh38

MGI Vertebrate Homology

Cd300c2 stringent orthology
1 human;1 mouse;4 rat;2 zebrafish
HCOP

vertebrate homology predictions: CD300C
Gene Tree

Cd300c2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele exhibit increased stimulated B cell proliferation.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

48
RefSeq

2
UniProt

5
CCDS

CCDS25616.1

Ensembl

ENSMUSG00000044811 (Evidence)
NCBI Gene

140497

			Length	Strain/Species	Flank
genomic	140497	NCBI Gene Model \| MGI Sequence Detail	5112	C57BL/6J	± kb
transcript	NM_134158	RefSeq \| MGI Sequence Detail	933	C57BL/6
polypeptide	Q7TSN2	UniProt \| EBI \| MGI Sequence Detail	228	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006191 CMRF35-like molecule 4

(term hierarchy)
InterPro Domains

IPR050671 CD300 family immune receptors

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain
GlyGen

Q7TSN2 1 site

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All nucleic 17

cDNA 17

Microarray probesets 3

Summaries

All 32

Gene Ontology 5

Phenotypes 6
Earliest

J:71672 Luo K, et al., DIgR1, a novel membrane receptor of the immunoglobulin gene superfamily, is preferentially expressed by antigen-presenting cells. Biochem Biophys Res Commun. 2001 Sep 14;287(1):35-41
Latest

J:282070 Nakazawa Y, et al., Cutting Edge: Involvement of the Immunoreceptor CD300c2 on Alveolar Macrophages in Bleomycin-Induced Lung Fibrosis. J Immunol. 2019 Dec 15;203(12):3107-3111

TSS for Cd300c2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111712	Chr11:114892468-114892471 (-)	236 bp
Tssr111711	Chr11:114892413-114892464 (-)	267 bp
Tssr111710	Chr11:114890085-114890108 (-)	2,609 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24