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Rnf34 Gene Detail
Summary
  • Symbol
    Rnf34
  • Name
    ring finger protein 34
  • Synonyms
    MGC:7670, phafin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153340
    NCBI Gene: 80751
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122988270-123007008 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    491 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153340
 protein coding gene Chr5:122988111-123009354 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030059
 protein coding gene Chr5:126523382-126547458 (+)
A/J MGP_AJ_G0030024
 protein coding gene Chr5:121269954-121291668 (+)
AKR/J MGP_AKRJ_G0029960
 protein coding gene Chr5:125176945-125201262 (+)
BALB/cJ MGP_BALBcJ_G0030035
 protein coding gene Chr5:122616987-122639039 (+)
C3H/HeJ MGP_C3HHeJ_G0029752
 protein coding gene Chr5:125802493-125823256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030488
 protein coding gene Chr5:131390411-131415213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027714
 protein coding gene Chr5:115868824-115892743 (+)
CAST/EiJ MGP_CASTEiJ_G0029161
 protein coding gene Chr5:124894619-124917130 (+)
CBA/J MGP_CBAJ_G0029722
 protein coding gene Chr5:136539182-136564290 (+)
DBA/2J MGP_DBA2J_G0029872
 protein coding gene Chr5:121327374-121350049 (+)
FVB/NJ MGP_FVBNJ_G0029828
 protein coding gene Chr5:120325165-120346473 (+)
LP/J MGP_LPJ_G0029961
 protein coding gene Chr5:127054541-127079780 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029859
 protein coding gene Chr5:140230450-140254274 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030529
 protein coding gene Chr5:124774871-124800927 (+)
PWK/PhJ MGP_PWKPhJ_G0028875
 protein coding gene Chr5:120112421-120132684 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028712
 protein coding gene Chr5:122481182-122503076 (+)
WSB/EiJ MGP_WSBEiJ_G0029236
 protein coding gene Chr5:125444318-125467772 (+)



Homology
more
  • Human Ortholog
    RNF34, ring finger protein 34
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF34, ring finger protein 34
  • Synonyms
    CARP-1, CARP1, hRFI, RFI, RIF, RIFF
  • Links
    NCBI Gene ID: 80196
    neXtProt AC: NX_Q969K3
    UniProt: Q969K3

  • Chr Location
    12q24.31; chr12:121400083-121430623 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    30
  • cDNA Data
    18
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80751 NCBI Gene Model | MGI Sequence Detail 18739 C57BL/6J ±  kb
transcript NM_001417908 RefSeq | MGI Sequence Detail 2059 C57BL/6  
polypeptide Q99KR6 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014131 E3 ubiquitin-protein ligase RNF34
    (term hierarchy)
  • EC
    2.3.2.27
  • InterPro Domains
    IPR049320 E3 ubiquitin-protein ligase CARP1/2, FYVE/PHD zinc finger
    IPR049323 E3 ubiquitin-protein ligase CARP1, FYVE/PHD zinc finger
    IPR051728 RING-FYVE domain-containing E3 ubiquitin-protein ligase
    IPR036361 SAP domain superfamily
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
  • GlyGen
    Q99KR6 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 4
Other
Accession IDs
less
MGI:2136842, MGI:2141146, MGI:2141205, MGI:2141347
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:322258 Fang S, et al., RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation. Neurobiol Dis. 2021 Aug;156:105396
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory