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Itga10 Gene Detail
Summary
  • Symbol
    Itga10
  • Name
    integrin, alpha 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153482
    NCBI Gene: 213119
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96552900-96571835 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 41.93 cM, cytoband F2.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    454 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153482
 protein coding gene Chr3:96552900-96571835 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027627
 protein coding gene Chr3:97532364-97553253 (+)
A/J MGP_AJ_G0027589
 protein coding gene Chr3:94412170-94431338 (+)
AKR/J MGP_AKRJ_G0027556
 protein coding gene Chr3:96636478-96656829 (+)
BALB/cJ MGP_BALBcJ_G0027599
 protein coding gene Chr3:94222581-94242405 (+)
C3H/HeJ MGP_C3HHeJ_G0027331
 protein coding gene Chr3:96944240-96963018 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028045
 protein coding gene Chr3:101092098-101112105 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025386
 protein coding gene Chr3:90689974-90709702 (+)
CAST/EiJ MGP_CASTEiJ_G0026786
 protein coding gene Chr3:96199014-96222381 (+)
CBA/J MGP_CBAJ_G0027306
 protein coding gene Chr3:104792189-104811610 (+)
DBA/2J MGP_DBA2J_G0027449
 protein coding gene Chr3:93742313-93762911 (+)
FVB/NJ MGP_FVBNJ_G0027418
 protein coding gene Chr3:91753748-91773234 (+)
LP/J MGP_LPJ_G0027554
 protein coding gene Chr3:98817306-98836151 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027444
 protein coding gene Chr3:110881322-110900933 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028099
 protein coding gene Chr3:96254992-96274573 (+)
PWK/PhJ MGP_PWKPhJ_G0026511
 protein coding gene Chr3:93577552-93596719 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026333
 protein coding gene Chr3:94557551-94576199 (+)
WSB/EiJ MGP_WSBEiJ_G0026864
 protein coding gene Chr3:96703210-96724221 (+)



Homology
more
  • Human Ortholog
    ITGA10, integrin subunit alpha 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA10, integrin subunit alpha 10
  • Synonyms
    PRO827
  • Links
    NCBI Gene ID: 8515
    neXtProt AC: NX_O75578
    UniProt: O75578

  • Chr Location
    1q21.1; chr1:145891208-145910111 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display slightly shortened long bones and amild abnormalities in ephysiseal plate morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    35
  • cDNA Data
    14
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213119 NCBI Gene Model | MGI Sequence Detail 18936 C57BL/6J ±  kb
    transcript NM_001302471 RefSeq | MGI Sequence Detail 5041 C57BL/6  
    polypeptide NP_001289400 RefSeq | MGI Sequence Detail 1166 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      E9Q6R1 2 sites, 4 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory