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Strc Gene Detail
Summary
  • Symbol
    Strc
  • Name
    stereocilin
  • Synonyms
    DFNB16
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153816
    NCBI Gene: 140476
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121193729-121211851 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153816
protein coding gene Chr2:121193729-121217649 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026389
protein coding gene Chr2:124253632-124278250 (-)
A/J MGP_AJ_G0026350
protein coding gene Chr2:119176687-119199920 (-)
AKR/J MGP_AKRJ_G0026329
protein coding gene Chr2:122522892-122546087 (-)
BALB/cJ MGP_BALBcJ_G0026363
protein coding gene Chr2:119410595-119433834 (-)
C3H/HeJ MGP_C3HHeJ_G0026109
protein coding gene Chr2:123000696-123024700 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026810
protein coding gene Chr2:128326501-128349999 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024190
protein coding gene Chr2:114221205-114246104 (-)
CAST/EiJ MGP_CASTEiJ_G0025571
protein coding gene Chr2:123326799-123350854 (-)
CBA/J MGP_CBAJ_G0026085
protein coding gene Chr2:132791991-132815180 (-)
DBA/2J MGP_DBA2J_G0026224
protein coding gene Chr2:118572796-118597011 (-)
FVB/NJ MGP_FVBNJ_G0026186
protein coding gene Chr2:117392877-117417803 (-)
LP/J MGP_LPJ_G0026325
protein coding gene Chr2:124510382-124533455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026205
protein coding gene Chr2:137071025-137094270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026865
protein coding gene Chr2:122637956-122661537 (-)
PWK/PhJ MGP_PWKPhJ_G0025307
protein coding gene Chr2:118184149-118207995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025106
protein coding gene Chr2:121845295-121869104 (-)
WSB/EiJ MGP_WSBEiJ_G0025640
protein coding gene Chr2:123462727-123487177 (-)



Homology
more
  • Human Ortholog
    STRC, stereocilin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRC, stereocilin
  • Synonyms
    DFNB16
  • Links
    NCBI Gene ID: 161497
    neXtProt AC: NX_Q7RTU9
    UniProt: Q7RTU9

  • Chr Location
    15q15.3; chr15:43599563-43618800 (-)  GRCh38

  • Human Ortholog
    STRCP1, stereocilin pseudogene 1
  • Synonyms
    STRCP
  • Links
    NCBI Gene ID: 554225
    UniProt: A6NGW2

  • Chr Location
    15q15.3; chr15:43699418-43718260 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Strc mouse models; 2 with human STRC associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit progressive hearing loss from P15 with abnormal cochlear outer hair cell stereociliary bundle morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140476 NCBI Gene Model | MGI Sequence Detail 18123 C57BL/6J ±  kb
    transcript NM_080459 RefSeq | MGI Sequence Detail 5757 Not Specified  
    polypeptide Q8VIM6 UniProt | EBI | MGI Sequence Detail 1809 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      Genomic 1
      cDNA 2
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory