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Plxnb1 Gene Detail
Summary
  • Symbol
    Plxnb1
  • Name
    plexin B1
  • Synonyms
    2900002G15Rik, mKIAA0407
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154238
    NCBI Gene: 235611
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108924457-108948985 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    554 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154238
 protein coding gene Chr9:108922915-108948985 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035327
 protein coding gene Chr9:111053967-111079331 (+)
A/J MGP_AJ_G0035306
 protein coding gene Chr9:106967422-106993700 (+)
AKR/J MGP_AKRJ_G0035238
 protein coding gene Chr9:109662128-109688754 (+)
BALB/cJ MGP_BALBcJ_G0035300
 protein coding gene Chr9:106669302-106695362 (+)
C3H/HeJ MGP_C3HHeJ_G0035010
 protein coding gene Chr9:110056005-110081365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035820
 protein coding gene Chr9:114082071-114106707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032718
 protein coding gene Chr9:104375544-104400411 (+)
CAST/EiJ MGP_CASTEiJ_G0034321
 protein coding gene Chr9:110025528-110051116 (+)
CBA/J MGP_CBAJ_G0034978
 protein coding gene Chr9:118102732-118130934 (+)
DBA/2J MGP_DBA2J_G0035139
 protein coding gene Chr9:106425061-106449757 (+)
FVB/NJ MGP_FVBNJ_G0035087
 protein coding gene Chr9:105244626-105272369 (+)
LP/J MGP_LPJ_G0035215
 protein coding gene Chr9:111241732-111269083 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035126
 protein coding gene Chr9:119658699-119685252 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035841
 protein coding gene Chr9:109931402-109956035 (+)
PWK/PhJ MGP_PWKPhJ_G0034028
 protein coding gene Chr9:106761503-106786405 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033863
 protein coding gene Chr9:109998983-110024309 (+)
WSB/EiJ MGP_WSBEiJ_G0034442
 protein coding gene Chr9:109832176-109857095 (+)



Homology
more
  • Human Ortholog
    PLXNB1, plexin B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNB1, plexin B1
  • Synonyms
    PLEXIN-B1, PLXN5, SEP
  • Links
    NCBI Gene ID: 5364
    neXtProt AC: NX_O43157
    UniProt: O43157

  • Chr Location
    3p21.31; chr3:48403854-48430310 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are viable and fertile and show no apparent defects in development, adult histology or basic functional parameters. However, a transitory renal phenotype, characterized by increased ureteric branching and enlarged kidneys, is noted over early stages of renal development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    180
  • cDNA Data
    131
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053646 Ensembl Gene Model | MGI Sequence Detail 24529 C57BL/6J ±  kb
    transcript ENSMUST00000072093 Ensembl | MGI Sequence Detail 8649 Not Applicable  
    polypeptide ENSMUSP00000071966 Ensembl | MGI Sequence Detail 2119 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 132
      Primer pair 2
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917470, MGI:2143234
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 29
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345627 Adel SS, et al., Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation. Mol Cell Neurosci. 2024 Feb 6;128:103920
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory