Plxnb3 MGI Mouse Gene Detail - MGI:2154240

Symbol

Plxnb3
Name

plexin B3
Synonyms

Plxn6

Feature Type

protein coding gene
IDs

MGI:2154240
NCBI Gene: 140571
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:72800696-72816120 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.40 cM
Mapping Data

3 experiments

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2154240	protein coding gene	ChrX:72800564-72816120 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035818	protein coding gene	ChrX:69531811-69547804 (+)
A/J	MGP_AJ_G0035799	protein coding gene	ChrX:69728439-69744704 (+)
AKR/J	MGP_AKRJ_G0035724	protein coding gene	ChrX:71550001-71565412 (+)
BALB/cJ	MGP_BALBcJ_G0035784	protein coding gene	ChrX:68760306-68776124 (+)
C3H/HeJ	MGP_C3HHeJ_G0035489	protein coding gene	ChrX:70005884-70021367 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036314	protein coding gene	ChrX:71662513-71678352 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033158	protein coding gene	ChrX:68759843-68775094 (+)
CAST/EiJ	MGP_CASTEiJ_G0034780	protein coding gene	ChrX:55351423-55366964 (+)
CBA/J	MGP_CBAJ_G0035464	protein coding gene	ChrX:73641873-73657302 (+)
DBA/2J	MGP_DBA2J_G0035621	protein coding gene	ChrX:69187061-69202916 (+)
FVB/NJ	MGP_FVBNJ_G0035565	protein coding gene	ChrX:68518782-68533985 (+)
LP/J	MGP_LPJ_G0035706	protein coding gene	ChrX:70313874-70330379 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035603	protein coding gene	ChrX:76211450-76226888 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036336	protein coding gene	ChrX:69353733-69369157 (+)
PWK/PhJ	MGP_PWKPhJ_G0034479	protein coding gene	ChrX:53366764-53383061 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034313	protein coding gene	ChrX:56255153-56270614 (+)
WSB/EiJ	MGP_WSBEiJ_G0034921	protein coding gene	ChrX:68627332-68643018 (+)

Human Ortholog

PLXNB3, plexin B3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLXNB3, plexin B3
Synonyms

PLEXB3, PLEXR, PLXN6
Links

HGNC:9105

NCBI Gene ID: 5365

neXtProt AC: NX_Q9ULL4

UniProt: Q9ULL4
Chr Location

Xq28; chrX:153764196-153779346 (+) GRCh38

MGI Vertebrate Homology

Plxnb3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLXNB3
Gene Tree

Plxnb3

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for a knock-out allele exhibit normal retinal stratification.

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All GO Annotations

45
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

39
cDNA Data

10
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plxnb3

ZFIN plxnb3

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All Sequences

54
RefSeq

10
UniProt

2
CCDS

CCDS41013.1

Ensembl

ENSMUSG00000031385 (Evidence)
NCBI Gene

140571

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031385	Ensembl Gene Model \| MGI Sequence Detail	15425	C57BL/6J	± kb
transcript	ENSMUST00000002079	Ensembl \| MGI Sequence Detail	6030	Not Applicable
polypeptide	ENSMUSP00000002079	Ensembl \| MGI Sequence Detail	1902	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012898 plexin-B3

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR013548 Plexin, cytoplasmic RasGAP domain

IPR046800 Plexin, cytoplasmic RhoGTPase-binding domain

IPR031148 Plexin family

IPR002165 Plexin repeat

IPR041019 Plexin, TIG domain 1

IPR041362 Plexin, TIG domain 2

IPR016201 PSI domain

IPR008936 Rho GTPase activation protein

IPR001627 Sema domain

IPR036352 Sema domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q9QY40 12 sites, 6 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 12

Primer pair 1

Other 2

Microarray probesets 4

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MGI:2147891, MGI:2154211

Summaries

All 53

Developmental Gene Expression 12

Gene Ontology 9

Phenotypes 7
Earliest

J:72426 Cheng HJ, et al., Plexin-a3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron. 2001 Oct 25;32(2):249-63
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plxnb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161289	ChrX:72800650-72800667 (+)	-37 bp
Tssr161290	ChrX:72800675-72800717 (+)	0 bp
Tssr161291	ChrX:72809125-72809190 (+)	8,462 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24