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Bicra Gene Detail
Summary
  • Symbol
    Bicra
  • Name
    BRD4 interacting chromatin remodeling complex associated protein
  • Synonyms
    Gltscr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154263
    NCBI Gene: 243842
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15704597-15781846 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.67 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154263
 protein coding gene Chr7:15704596-15785047 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031696
 protein coding gene Chr7:13617005-13644732 (-)
A/J MGP_AJ_G0031668
 protein coding gene Chr7:13430393-13458157 (-)
AKR/J MGP_AKRJ_G0031593
 protein coding gene Chr7:13720465-13755600 (-)
BALB/cJ MGP_BALBcJ_G0031675
 protein coding gene Chr7:13530190-13558244 (-)
C3H/HeJ MGP_C3HHeJ_G0031397
 protein coding gene Chr7:13903048-13934554 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032141
 protein coding gene Chr7:14358660-14387061 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029220
 protein coding gene Chr7:14987184-15015727 (-)
CAST/EiJ MGP_CASTEiJ_G0030748
 protein coding gene Chr7:10669444-10696829 (-)
CBA/J MGP_CBAJ_G0031356
 protein coding gene Chr7:14809400-14839765 (-)
DBA/2J MGP_DBA2J_G0031512
 protein coding gene Chr7:13318841-13346543 (-)
FVB/NJ MGP_FVBNJ_G0031468
 protein coding gene Chr7:13198881-13228587 (-)
LP/J MGP_LPJ_G0031597
 protein coding gene Chr7:13892993-13922961 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031503
 protein coding gene Chr7:14795306-14824236 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032170
 protein coding gene Chr7:13501878-13530209 (-)
PWK/PhJ MGP_PWKPhJ_G0030472
 protein coding gene Chr7:10822768-10851456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030300
 protein coding gene Chr7:8428387-8456409 (-)
WSB/EiJ MGP_WSBEiJ_G0030845
 protein coding gene Chr7:13541939-13569797 (-)



Homology
more
  • Human Ortholog
    BICRA, BRD4 interacting chromatin remodeling complex associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BICRA, BRD4 interacting chromatin remodeling complex associated protein
  • Synonyms
    CSS12, GLTSCR1, SMARCK1
  • Links
    NCBI Gene ID: 29998
    neXtProt AC: NX_Q9NZM4
    UniProt: Q9NZM4

  • Chr Location
    19q13.33; chr19:47608196-47703277 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BICRA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality between E15 and E16.5 associated with cardiac defects, growth retardation, and edema. Mice heterozygous for the allele exhibit reduced size and weight with reduced growth hormone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070808 Ensembl Gene Model | MGI Sequence Detail 77250 C57BL/6J ±  kb
    transcript ENSMUST00000210781 Ensembl | MGI Sequence Detail 5975 Not Applicable  
    polypeptide ENSMUSP00000148012 Ensembl | MGI Sequence Detail 1578 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008054 BRD4-interacting chromatin-remodeling complex-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR052438 Chromatin-remodeling and transcription coactivator
      IPR015671 GLTSCR protein, conserved domain
    • GlyGen
      F8VPZ9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 17
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:5883603
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:76561 Chae TH, et al., Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Mamm Genome. 2002 May;13(5):239-44
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory