Sesn1 MGI Mouse Gene Detail - MGI:2155278

Symbol

Sesn1
Name

sestrin 1
Synonyms

1110002G11Rik, PA26, SEST1

Feature Type

protein coding gene
IDs

MGI:2155278
NCBI Gene: 140742
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:41686570-41784432 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.77 cM
Mapping Data

3 experiments

SNPs within 2kb

2033 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155278	protein coding gene	Chr10:41685931-41784432 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017181	protein coding gene	Chr10:40474553-40573911 (+)
A/J	MGP_AJ_G0017158	protein coding gene	Chr10:39351059-39439966 (+)
AKR/J	MGP_AKRJ_G0017118	protein coding gene	Chr10:39952647-40049029 (+)
BALB/cJ	MGP_BALBcJ_G0017120	protein coding gene	Chr10:39414386-39510343 (+)
C3H/HeJ	MGP_C3HHeJ_G0016941	protein coding gene	Chr10:40269530-40363216 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017579	protein coding gene	Chr10:41706017-41809350 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015275	protein coding gene	Chr10:37250146-37328416 (+)
CAST/EiJ	MGP_CASTEiJ_G0016520	protein coding gene	Chr10:40468124-40562018 (+)
CBA/J	MGP_CBAJ_G0016915	protein coding gene	Chr10:43609788-43724460 (+)
DBA/2J	MGP_DBA2J_G0017020	protein coding gene	Chr10:38851332-38941229 (+)
FVB/NJ	MGP_FVBNJ_G0017015	protein coding gene	Chr10:38343247-38434655 (+)
LP/J	MGP_LPJ_G0017097	protein coding gene	Chr10:40471632-40571224 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017045	protein coding gene	Chr10:44414370-44517947 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017616	protein coding gene	Chr10:39911533-40005532 (+)
PWK/PhJ	MGP_PWKPhJ_G0016300	protein coding gene	Chr10:38725031-38814180 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016084	protein coding gene	Chr10:39740544-39833268 (+)
WSB/EiJ	MGP_WSBEiJ_G0016583	protein coding gene	Chr10:40238603-40333643 (+)

Human Ortholog

SESN1, sestrin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SESN1, sestrin 1
Synonyms

PA26, SEST1
Links

HGNC:21595

NCBI Gene ID: 27244

neXtProt AC: NX_Q9Y6P5

UniProt: Q9Y6P5
Chr Location

6q21; chr6:108984309-109094846 (-) GRCh38

MGI Vertebrate Homology

Sesn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SESN1
Gene Tree

Sesn1

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

9
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Sesn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a kncok-out allele exhibit enhanced responsiveness to an influenza vaccine in aged mice.

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All GO Annotations

32
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

52
cDNA Data

76
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sesn1

ZFIN sesn1

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All Sequences

58
RefSeq

4
UniProt

4
CCDS

CCDS23809.1, CCDS48550.1

Ensembl

ENSMUSG00000038332 (Evidence)
NCBI Gene

140742

			Length	Strain/Species	Flank
genomic	140742	NCBI Gene Model \| MGI Sequence Detail	97863	C57BL/6J	± kb
transcript	NM_001162908	RefSeq \| MGI Sequence Detail	3182	ZRU/MplStud
polypeptide	P58006	UniProt \| EBI \| MGI Sequence Detail	492	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014714 sestrin-1

(term hierarchy)
EC

1.11.1.-
InterPro Domains

IPR029032 AhpD-like

IPR006730 Sestrin

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All nucleic 77

cDNA 76

Primer pair 1

Microarray probesets 4

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MGI:1915788, MGI:2143767

Summaries

All 62

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 24
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sesn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93064	Chr10:41685944-41685959 (+)	-618 bp
Tssr93065	Chr10:41685994-41686009 (+)	-568 bp
Tssr93066	Chr10:41686169-41686241 (+)	-365 bp
Tssr93067	Chr10:41686524-41686576 (+)	-20 bp
Tssr93068	Chr10:41686840-41686857 (+)	279 bp
Tssr93069	Chr10:41763424-41763451 (+)	76,868 bp
Tssr93070	Chr10:41763453-41763494 (+)	76,904 bp
Tssr93071	Chr10:41769943-41769955 (+)	83,379 bp
Tssr93072	Chr10:41769963-41769974 (+)	83,399 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24