Sec63 MGI Mouse Gene Detail - MGI:2155302 - SEC63 homolog, protein translocation regulator

Symbol

Sec63
Name

SEC63 homolog, protein translocation regulator
Synonyms

5730478J10Rik

Feature Type

protein coding gene
IDs

MGI:2155302
NCBI Gene: 140740
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:42637492-42708510 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.89 cM
Mapping Data

4 experiments

SNPs within 2kb

1591 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155302	protein coding gene	Chr10:42637492-42708510 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017188	protein coding gene	Chr10:41486315-41562442 (+)
A/J	MGP_AJ_G0017165	protein coding gene	Chr10:40330466-40401626 (+)
AKR/J	MGP_AKRJ_G0017125	protein coding gene	Chr10:40939018-41009514 (+)
BALB/cJ	MGP_BALBcJ_G0017127	protein coding gene	Chr10:40383340-40456617 (+)
C3H/HeJ	MGP_C3HHeJ_G0016948	protein coding gene	Chr10:41294122-41366245 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017586	protein coding gene	Chr10:42757026-42831222 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015282	protein coding gene	Chr10:38178665-38249166 (+)
CAST/EiJ	MGP_CASTEiJ_G0016527	protein coding gene	Chr10:41493937-41571500 (+)
CBA/J	MGP_CBAJ_G0016922	protein coding gene	Chr10:44749958-44821793 (+)
DBA/2J	MGP_DBA2J_G0017027	protein coding gene	Chr10:39813704-39885816 (+)
FVB/NJ	MGP_FVBNJ_G0017022	protein coding gene	Chr10:39301784-39374846 (+)
LP/J	MGP_LPJ_G0017104	protein coding gene	Chr10:41500701-41571901 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017052	protein coding gene	Chr10:45459807-45535146 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017623	protein coding gene	Chr10:40925542-41001372 (+)
PWK/PhJ	MGP_PWKPhJ_G0016307	protein coding gene	Chr10:39686983-39757910 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016091	protein coding gene	Chr10:40758969-40831378 (+)
WSB/EiJ	MGP_WSBEiJ_G0016590	protein coding gene	Chr10:41222746-41297722 (+)

Human Ortholog

SEC63, SEC63 homolog, protein translocation regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEC63, SEC63 homolog, protein translocation regulator
Synonyms

DNAJC23, ERdj2, PCLD2, PRO2507, SEC63L
Links

HGNC:21082

NCBI Gene ID: 11231

neXtProt AC: NX_Q9UGP8

UniProt: Q9UGP8
Chr Location

6q21; chr6:107867756-107958208 (-) GRCh38

MGI Vertebrate Homology

Sec63 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEC63
Gene Tree

Sec63

Diseases

1 with human SEC63 associations

				Human Disease	Mouse Models
				polycystic liver disease 2 IDs polycystic liver disease 2 DOID:0060975 OMIM:617004

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 3 alleles in 4 genetic backgrounds
8 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Sec63
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice homozygous for a conditional allele activated in the kidneys or ubiquitously develop polycystic kidney and liver phenotypes, respectively.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

19
cDNA Data

119
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec63

ZFIN sec63

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All Sequences

68
RefSeq

10
UniProt

3
CCDS

CCDS23815.1

Ensembl

ENSMUSG00000019802 (Evidence)
NCBI Gene

140740

			Length	Strain/Species	Flank
genomic	140740	NCBI Gene Model \| MGI Sequence Detail	71019	C57BL/6J	± kb
transcript	NM_153055	RefSeq \| MGI Sequence Detail	6058	C57BL/6
polypeptide	Q8VHE0	UniProt \| EBI \| MGI Sequence Detail	760	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014600 translocation protein SEC63

(term hierarchy)
InterPro Domains

IPR035892 C2 domain superfamily

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR014756 Immunoglobulin E-set

IPR004179 Sec63 domain
GlyGen

Q8VHE0 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 120

Genomic 1

cDNA 119

Microarray probesets 10

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MGI:1917835, MGI:2143660, MGI:2143832

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 21
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sec63:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93103	Chr10:42637479-42637486 (+)	-9 bp
Tssr93104	Chr10:42637536-42637603 (+)	78 bp
Tssr93105	Chr10:42637605-42637659 (+)	140 bp
Tssr93106	Chr10:42643099-42643109 (+)	5,612 bp
Tssr93107	Chr10:42658526-42658542 (+)	21,042 bp
Tssr93108	Chr10:42682608-42682637 (+)	45,131 bp
Tssr93109	Chr10:42688427-42688456 (+)	50,950 bp
Tssr93110	Chr10:42703847-42703860 (+)	66,362 bp
Tssr93111	Chr10:42703869-42703881 (+)	66,383 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24