Bmp2k MGI Mouse Gene Detail - MGI:2155456

Symbol

Bmp2k
Name

BMP2 inducible kinase
Synonyms

4933417M22Rik, BIKE

Feature Type

protein coding gene
IDs

MGI:2155456
NCBI Gene: 140780
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:97145548-97239726 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 47.29 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

2574 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2155456	protein coding gene	Chr5:97143588-97239809 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029767	protein coding gene	Chr5:98274071-98369359 (+)
A/J	MGP_AJ_G0029733	protein coding gene	Chr5:94648662-94743566 (+)
AKR/J	MGP_AKRJ_G0029679	protein coding gene	Chr5:97810103-97907485 (+)
BALB/cJ	MGP_BALBcJ_G0029743	protein coding gene	Chr5:95654868-95750442 (+)
C3H/HeJ	MGP_C3HHeJ_G0029466	protein coding gene	Chr5:98141752-98239694 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030198	protein coding gene	Chr5:102447958-102547457 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027433	protein coding gene	Chr5:90019052-90116880 (+)
CAST/EiJ	MGP_CASTEiJ_G0028876	protein coding gene	Chr5:96742141-96841227 (+)
CBA/J	MGP_CBAJ_G0029436	protein coding gene	Chr5:105966903-106071209 (+)
DBA/2J	MGP_DBA2J_G0029580	protein coding gene	Chr5:94857961-94952140 (+)
FVB/NJ	MGP_FVBNJ_G0029539	protein coding gene	Chr5:93681807-93778245 (+)
LP/J	MGP_LPJ_G0029668	protein coding gene	Chr5:98923460-99023392 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029568	protein coding gene	Chr5:111047908-111145478 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030231	protein coding gene	Chr5:97250145-97348998 (+)
PWK/PhJ	MGP_PWKPhJ_G0028595	protein coding gene	Chr5:93247969-93343735 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028430	protein coding gene	Chr5:94907548-95003671 (+)
WSB/EiJ	MGP_WSBEiJ_G0028955	protein coding gene	Chr5:97561050-97659561 (+)

Human Ortholog

BMP2K, BMP2 inducible kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BMP2K, BMP2 inducible kinase
Synonyms

BIKE, HRIHFB2017
Links

HGNC:18041

NCBI Gene ID: 55589

neXtProt AC: NX_Q9NSY1

UniProt: Q9NSY1
Chr Location

4q21.21; chr4:78776342-78916365 (+) GRCh38

MGI Vertebrate Homology

Bmp2k stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BMP2K
Gene Tree

Bmp2k

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Spontaneous

1
Genomic Mutations

3 involving Bmp2k
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

38
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

5
cDNA Data

14
Literature Summary

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bmp2k

ZFIN bmp2k

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All Sequences

52
RefSeq

10
UniProt

2
CCDS

CCDS39175.1

Ensembl

ENSMUSG00000034663 (Evidence)
NCBI Gene

140780

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034663	Ensembl Gene Model \| MGI Sequence Detail	94179	C57BL/6J	± kb
transcript	ENSMUST00000035635	Ensembl \| MGI Sequence Detail	7387	Not Applicable
polypeptide	ENSMUSP00000037970	Ensembl \| MGI Sequence Detail	1138	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004773 BMP-2-inducible protein kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR051744 AP2-associated Ser/Thr protein kinase

IPR028182 BMP-2-inducible protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q91Z96 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 6

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MGI:1918364, MGI:2140784, MGI:3034367

Summaries

All 48

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bmp2k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47422	Chr5:97143879-97143892 (+)	-1,662 bp
Tssr1552	Chr5:97145297-97145344 (+)	-227 bp
Tssr47423	Chr5:97145535-97145625 (+)	32 bp
Tssr47424	Chr5:97154372-97154381 (+)	8,829 bp
Tssr47425	Chr5:97196657-97196665 (+)	51,113 bp
Tssr47426	Chr5:97196735-97196747 (+)	51,193 bp
Tssr47427	Chr5:97238681-97238706 (+)	93,146 bp
Tssr47428	Chr5:97239108-97239112 (+)	93,562 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24