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Myh7 Gene Detail
Summary
  • Symbol
    Myh7
  • Name
    myosin, heavy polypeptide 7, cardiac muscle, beta
  • Synonyms
    beta-MHC, betaMHC, B-MHC, MYH-beta/slow, Myhc-b, Myhcb, MyHC-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155600
    NCBI Gene: 140781
  • Alliance
    gene page
  • Transcription Start Sites
    47 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55208141-55232083 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    724 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155600
 protein coding gene Chr14:55208141-55232083 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021335
 protein coding gene Chr14:48956583-48986862 (-)
A/J MGP_AJ_G0021294
 protein coding gene Chr14:47990125-48013707 (-)
AKR/J MGP_AKRJ_G0021271
 protein coding gene Chr14:49757860-49759692 (-)
BALB/cJ MGP_BALBcJ_G0021298
 protein coding gene Chr14:47966473-47991195 (-)
C3H/HeJ MGP_C3HHeJ_G0021078
 protein coding gene Chr14:49430002-49453544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021736
 protein coding gene Chr14:51430588-51464175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019283
 protein coding gene Chr14:46401639-46425271 (-)
CAST/EiJ MGP_CASTEiJ_G0020597
 protein coding gene Chr14:45668595-45696632 (-)
CBA/J MGP_CBAJ_G0021045
 protein coding gene Chr14:52991685-53023910 (-)
DBA/2J MGP_DBA2J_G0021166
 protein coding gene Chr14:47731209-47754697 (-)
FVB/NJ MGP_FVBNJ_G0021148
 protein coding gene Chr14:47193916-47220953 (-)
LP/J MGP_LPJ_G0021240
 protein coding gene Chr14:50021255-50035360 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021172
 protein coding gene Chr14:52373596-52400460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021763
 protein coding gene Chr14:48916875-48948398 (-)
PWK/PhJ MGP_PWKPhJ_G0020344
 protein coding gene Chr14:44268096-44293106 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020172
 protein coding gene Chr14:44898771-44924904 (-)
WSB/EiJ MGP_WSBEiJ_G0020650
 protein coding gene Chr14:49211671-49239817 (-)



Homology
more
  • Human Ortholog
    MYH7, myosin heavy chain 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH7, myosin heavy chain 7
  • Synonyms
    CMD1S, CMH1, CMYO7A, CMYO7B, CMYP7A, CMYP7B, MPD1, MYHCB, SPMD, SPMM
  • Links
    NCBI Gene ID: 4625
    neXtProt AC: NX_P12883
    UniProt: P12883

  • Chr Location
    14q11.2; chr14:23412740-23435660 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human MYH7 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an endonuclease-mediated allele exhibit complete embryonic lethality during organogenesis with evidence of heart failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1158
  • Tissues
    113
  • cDNA Data
    17
  • Literature Summary
    208
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140781 NCBI Gene Model | MGI Sequence Detail 23943 C57BL/6J ±  kb
    transcript NM_001361607 RefSeq | MGI Sequence Detail 6313 ZRU/MplStud  
    polypeptide Q91Z83 UniProt | EBI | MGI Sequence Detail 1935 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 2
      cDNA 22
      Primer pair 33
      Other 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12742, MGD-MRK-12744, MGI:97256
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 208
      Diseases 2
      Gene Ontology 14
      Phenotypes 25
    • Earliest
      J:8079 Weydert A, et al., Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
    • Latest
      J:351081 Fukushima T, et al., PHF2 regulates sarcomeric gene transcription in myogenesis. PLoS One. 2024;19(5):e0301690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory