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P2ry14 Gene Detail
Summary
  • Symbol
    P2ry14
  • Name
    purinergic receptor P2Y, G-protein coupled, 14
  • Synonyms
    A330108O13Rik, Gpr105, P2Y14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155705
    NCBI Gene: 140795
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:59022044-59060913 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 28.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155705
 protein coding gene Chr3:59021276-59061039 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027243
 protein coding gene Chr3:57989215-58030066 (-)
A/J MGP_AJ_G0027203
 protein coding gene Chr3:56174528-56214303 (-)
AKR/J MGP_AKRJ_G0027173
 protein coding gene Chr3:57342578-57382060 (-)
BALB/cJ MGP_BALBcJ_G0027216
 protein coding gene Chr3:55981540-56021290 (-)
C3H/HeJ MGP_C3HHeJ_G0026959
 protein coding gene Chr3:57565600-57605813 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027662
 protein coding gene Chr3:60129560-60171070 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025016
 protein coding gene Chr3:52524001-52568212 (-)
CAST/EiJ MGP_CASTEiJ_G0026411
 protein coding gene Chr3:57734361-57773857 (-)
CBA/J MGP_CBAJ_G0026935
 protein coding gene Chr3:62117204-62156836 (-)
DBA/2J MGP_DBA2J_G0027069
 protein coding gene Chr3:55684493-55724133 (-)
FVB/NJ MGP_FVBNJ_G0027037
 protein coding gene Chr3:54637092-54676732 (-)
LP/J MGP_LPJ_G0027181
 protein coding gene Chr3:58747069-58787623 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027055
 protein coding gene Chr3:66263861-66304553 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027720
 protein coding gene Chr3:57310523-57350798 (-)
PWK/PhJ MGP_PWKPhJ_G0026143
 protein coding gene Chr3:55312262-55353652 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025956
 protein coding gene Chr3:57008196-57053702 (-)
WSB/EiJ MGP_WSBEiJ_G0026485
 protein coding gene Chr3:57387465-57427667 (-)



Homology
more
  • Human Ortholog
    P2RY14, purinergic receptor P2Y14
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY14, purinergic receptor P2Y14
  • Synonyms
    BPR105, GPR105, P2Y14
  • Links
    NCBI Gene ID: 9934
    neXtProt AC: NX_Q15391
    UniProt: Q15391

  • Chr Location
    3q25.1; chr3:151212117-151278542 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele fail to exhibit increased glucose mediated forestomach muscle tension. Mice homozygous for a different null allele show decreased gastrointestinal emptying, impaired glucose tolerance, decreased glucose-stimulated insulin release, and reduced airway responsiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140795 NCBI Gene Model | MGI Sequence Detail 38870 C57BL/6J ±  kb
    transcript NM_001287123 RefSeq | MGI Sequence Detail 1994 ZRU/MplStud  
    polypeptide Q9ESG6 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2441794
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:113918 Chambers JK, et al., A G protein-coupled receptor for UDP-glucose. J Biol Chem. 2000 Apr 14;275(15):10767-71
    • Latest
      J:357394 Patritti-Cram J, et al., NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14. iScience. 2024 Jul 19;27(7):110294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory