About   Help   FAQ
Slc17a6 Gene Detail
Summary
  • Symbol
    Slc17a6
  • Name
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
  • Synonyms
    2900073D12Rik, VGLUT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156052
    NCBI Gene: 140919
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:51271754-51320867 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 32.78 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1567 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156052
 protein coding gene Chr7:51271578-51320874 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032305
 protein coding gene Chr7:52369152-52418388 (+)
A/J MGP_AJ_G0032284
 protein coding gene Chr7:51552767-51601991 (+)
AKR/J MGP_AKRJ_G0032220
 protein coding gene Chr7:52765535-52814755 (+)
BALB/cJ MGP_BALBcJ_G0032296
 protein coding gene Chr7:51202753-51251909 (+)
C3H/HeJ MGP_C3HHeJ_G0032009
 protein coding gene Chr7:53174900-53225580 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032789
 protein coding gene Chr7:54733730-54783499 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029795
 protein coding gene Chr7:54584385-54637175 (+)
CAST/EiJ MGP_CASTEiJ_G0031337
 protein coding gene Chr7:44479371-44532506 (+)
CBA/J MGP_CBAJ_G0031974
 protein coding gene Chr7:56595381-56644667 (+)
DBA/2J MGP_DBA2J_G0032131
 protein coding gene Chr7:50733327-50783067 (+)
FVB/NJ MGP_FVBNJ_G0032085
 protein coding gene Chr7:50653392-50703108 (+)
LP/J MGP_LPJ_G0032212
 protein coding gene Chr7:53328216-53377499 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032122
 protein coding gene Chr7:55682591-55737685 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032806
 protein coding gene Chr7:51734307-51783251 (+)
PWK/PhJ MGP_PWKPhJ_G0031057
 protein coding gene Chr7:44036721-44086979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030898
 protein coding gene Chr7:39916076-39965242 (+)
WSB/EiJ MGP_WSBEiJ_G0031455
 protein coding gene Chr7:52437331-52487091 (+)



Homology
more
  • Human Ortholog
    SLC17A6, solute carrier family 17 member 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC17A6, solute carrier family 17 member 6
  • Synonyms
    DNPI, VGLUT2
  • Links
    NCBI Gene ID: 57084
    neXtProt AC: NX_Q9P2U8
    UniProt: Q9P2U8

  • Chr Location
    11p14.3; chr11:22338381-22379503 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 7 alleles in 7 genetic backgrounds
    30 phenotypes from multigenic genotypes
    614 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display neonatal lethality, respiratory failure, and abnormal nervous system physiology. Heterozygous mice for one allele display abnormal miniature EPSC and reduced responses to neuropathic pain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1180
  • Tissues
    143
  • cDNA Data
    38
  • Literature Summary
    225
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030500 Ensembl Gene Model | MGI Sequence Detail 49114 C57BL/6J ±  kb
    transcript ENSMUST00000032710 Ensembl | MGI Sequence Detail 4137 Not Applicable  
    polypeptide ENSMUSP00000032710 Ensembl | MGI Sequence Detail 582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014962 vesicular glutamate transporter 2
      (term hierarchy)
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR050382 Major Facilitator Superfamily Sodium/Anion Cotransporter
      IPR036259 MFS transporter superfamily
    • GlyGen
      Q8BLE7 3 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 42
      Primer pair 3
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920305
    References
    more
    • Summaries
      All 870
      Developmental Gene Expression 225
      Gene Ontology 12
      Phenotypes 614
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:358172 Wei J, et al., A distributed auditory network mediated by pontine central gray underlies ultra-fast awakening in response to alerting sounds. Curr Biol. 2024 Oct 21;34(20):4597-4611.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory