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Recql5 Gene Detail
Summary
  • Symbol
    Recql5
  • Name
    RecQ protein-like 5
  • Synonyms
    Recq5b, Recql5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156841
    NCBI Gene: 170472
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115783421-115824303 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1093 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156841
 protein coding gene Chr11:115783421-115824339 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019404
 protein coding gene Chr11:119968923-120011210 (-)
A/J MGP_AJ_G0019373
 protein coding gene Chr11:114720158-114762470 (-)
AKR/J MGP_AKRJ_G0019343
 protein coding gene Chr11:118147194-118191974 (-)
BALB/cJ MGP_BALBcJ_G0019347
 protein coding gene Chr11:115135942-115177335 (-)
C3H/HeJ MGP_C3HHeJ_G0019153
 protein coding gene Chr11:118490886-118538285 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019797
 protein coding gene Chr11:123627088-123671120 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017420
 protein coding gene Chr11:111745610-111786004 (-)
CAST/EiJ MGP_CASTEiJ_G0018708
 protein coding gene Chr11:119836591-119882363 (-)
CBA/J MGP_CBAJ_G0019125
 protein coding gene Chr11:128523279-128564435 (-)
DBA/2J MGP_DBA2J_G0019236
 protein coding gene Chr11:114143017-114184612 (-)
FVB/NJ MGP_FVBNJ_G0019228
 protein coding gene Chr11:113646668-113694001 (-)
LP/J MGP_LPJ_G0019306
 protein coding gene Chr11:120349167-120390312 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019261
 protein coding gene Chr11:127632254-127676749 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019835
 protein coding gene Chr11:118797800-118842240 (-)
PWK/PhJ MGP_PWKPhJ_G0018472
 protein coding gene Chr11:115460699-115501989 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018265
 protein coding gene Chr11:118548632-118594183 (-)
WSB/EiJ MGP_WSBEiJ_G0018760
 protein coding gene Chr11:118765618-118806459 (-)



Homology
more
  • Human Ortholog
    RECQL5, RecQ like helicase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RECQL5, RecQ like helicase 5
  • Synonyms
    RECQ5
  • Links
    NCBI Gene ID: 9400
    neXtProt AC: NX_O94762
    UniProt: O94762

  • Chr Location
    17q25.1; chr17:75626845-75667189 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene express elevated levels of sister chromatid exchange due to a failure to suppress crossovers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020752 Ensembl Gene Model | MGI Sequence Detail 40883 C57BL/6J ±  kb
transcript ENSMUST00000021097 Ensembl | MGI Sequence Detail 3971 Not Applicable  
polypeptide ENSMUSP00000021097 Ensembl | MGI Sequence Detail 982 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013862 ATP-dependent DNA helicase Q5
    (term hierarchy)
  • EC
    5.6.2.4
  • InterPro Domains
    IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain
    IPR011545 DEAD/DEAH box helicase domain
    IPR004589 DNA helicase, ATP-dependent, RecQ type
    IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
    IPR001650 Helicase, C-terminal domain-like
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR010716 RecQ helicase-like 5
    IPR013257 Set2 Rpb1 interacting domain
  • GlyGen
    Q8VID5 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:73673 Ohhata T, et al., Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta. Gene. 2001 Dec 12;280(1-2):59-66
  • Latest
    J:350435 Iwata S, et al., A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes. Genetics. 2024 Jun 5;227(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory