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Caskin2 Gene Detail
Summary
  • Symbol
    Caskin2
  • Name
    CASK-interacting protein 2
  • Synonyms
    1600028L06Rik, mKIAA1139
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157062
    NCBI Gene: 140721
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115690009-115704465 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2157062
 protein coding gene Chr11:115689813-115704517 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019400
 protein coding gene Chr11:119865850-119882293 (-)
A/J MGP_AJ_G0019369
 protein coding gene Chr11:114623058-114637600 (-)
AKR/J MGP_AKRJ_G0019339
 protein coding gene Chr11:118044599-118060288 (-)
BALB/cJ MGP_BALBcJ_G0019343
 protein coding gene Chr11:115040543-115054921 (-)
C3H/HeJ MGP_C3HHeJ_G0019149
 protein coding gene Chr11:118393760-118408130 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019793
 protein coding gene Chr11:123528977-123543354 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017416
 protein coding gene Chr11:111646634-111661612 (-)
CAST/EiJ MGP_CASTEiJ_G0018704
 protein coding gene Chr11:119733269-119749435 (-)
CBA/J MGP_CBAJ_G0019121
 protein coding gene Chr11:128417976-128432346 (-)
DBA/2J MGP_DBA2J_G0019232
 protein coding gene Chr11:114049265-114063643 (-)
FVB/NJ MGP_FVBNJ_G0019224
 protein coding gene Chr11:113545227-113562010 (-)
LP/J MGP_LPJ_G0019302
 protein coding gene Chr11:120247714-120262084 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019257
 protein coding gene Chr11:127530059-127544429 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019831
 protein coding gene Chr11:118696344-118710714 (-)
PWK/PhJ MGP_PWKPhJ_G0018468
 protein coding gene Chr11:115360098-115374894 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018261
 protein coding gene Chr11:118444214-118458650 (-)
WSB/EiJ MGP_WSBEiJ_G0018756
 protein coding gene Chr11:118658703-118673072 (-)



Homology
more
  • Human Ortholog
    CASKIN2, CASK interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CASKIN2, CASK interacting protein 2
  • Synonyms
    ANKS5B
  • Links
    NCBI Gene ID: 57513
    neXtProt AC: NX_Q8WXE0
    UniProt: Q8WXE0

  • Chr Location
    17q25.1; chr17:75500261-75515537 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Double homozygous knockout with Caskin1 affects synapse efficacy in the brain and leads to spatial learning and novel object recognition deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1034
  • Tissues
    52
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034471 Ensembl Gene Model | MGI Sequence Detail 14457 C57BL/6J ±  kb
    transcript ENSMUST00000041684 Ensembl | MGI Sequence Detail 4929 Not Applicable  
    polypeptide ENSMUSP00000041328 Ensembl | MGI Sequence Detail 1201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920493
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory