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Cdhr1 Gene Detail
Summary
  • Symbol
    Cdhr1
  • Name
    cadherin-related family member 1
  • Synonyms
    Pcdh21, Prcad
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157782
    NCBI Gene: 170677
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:36799814-36820304 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 21.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    819 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2157782
 protein coding gene Chr14:36799806-36820304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021187
 protein coding gene Chr14:30578760-30599176 (-)
A/J MGP_AJ_G0021135
 protein coding gene Chr14:29314003-29334424 (-)
AKR/J MGP_AKRJ_G0021112
 protein coding gene Chr14:30651407-30672146 (-)
BALB/cJ MGP_BALBcJ_G0021139
 protein coding gene Chr14:29546090-29566499 (-)
C3H/HeJ MGP_C3HHeJ_G0020922
 protein coding gene Chr14:30533626-30554063 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021571
 protein coding gene Chr14:31675294-31695765 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019133
 protein coding gene Chr14:29298173-29318372 (-)
CAST/EiJ MGP_CASTEiJ_G0020447
 protein coding gene Chr14:30421033-30441445 (-)
CBA/J MGP_CBAJ_G0020888
 protein coding gene Chr14:32857604-32878039 (-)
DBA/2J MGP_DBA2J_G0021011
 protein coding gene Chr14:29354567-29374988 (-)
FVB/NJ MGP_FVBNJ_G0020995
 protein coding gene Chr14:29331643-29352082 (-)
LP/J MGP_LPJ_G0021080
 protein coding gene Chr14:30874038-30894496 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021021
 protein coding gene Chr14:32060076-32080454 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021604
 protein coding gene Chr14:30513375-30533811 (-)
PWK/PhJ MGP_PWKPhJ_G0020195
 protein coding gene Chr14:28898631-28919172 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020019
 protein coding gene Chr14:30059683-30083876 (-)
WSB/EiJ MGP_WSBEiJ_G0020502
 protein coding gene Chr14:30539864-30560228 (-)



Homology
more
  • Human Ortholog
    CDHR1, cadherin related family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDHR1, cadherin related family member 1
  • Synonyms
    CORD15, PCDH21, PRCAD, RP65
  • Links
    NCBI Gene ID: 92211
    neXtProt AC: NX_Q96JP9
    UniProt: Q96JP9

  • Chr Location
    10q23.1; chr10:84194537-84219621 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CDHR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit progressive degeneration of retinal photoreceptor cells and a slight reduction in light responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    70
  • cDNA Data
    71
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021803 Ensembl Gene Model | MGI Sequence Detail 20491 C57BL/6J ±  kb
    transcript ENSMUST00000022337 Ensembl | MGI Sequence Detail 4332 Not Applicable  
    polypeptide ENSMUSP00000022337 Ensembl | MGI Sequence Detail 859 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 72
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 20
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:73286 Rattner A, et al., A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. Neuron. 2001 Dec 6;32(5):775-86
    • Latest
      J:332184 Cao Y, et al., Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Curr Biol. 2022 Nov 21;32(22):4783-4796.e3
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory