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Peg10 Gene Detail
Summary
  • Symbol
    Peg10
  • Name
    paternally expressed 10
  • Synonyms
    Edr, HB-1, Mar2, Mart2, MEF3L, MyEF-3, MyEF-3 like, Rtl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157785
    NCBI Gene: 170676
  • Alliance
    gene page
  • Transcription Start Sites
    81 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:4747306-4760517 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 1.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2157785
 protein coding gene Chr6:4747306-4760517 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030430
 protein coding gene Chr6:1521712-1536244 (+)
A/J MGP_AJ_G0030403
 protein coding gene Chr6:1465857-1478993 (+)
AKR/J MGP_AKRJ_G0030330
 protein coding gene Chr6:1523429-1536545 (+)
BALB/cJ MGP_BALBcJ_G0030412
 protein coding gene Chr6:1468702-1482154 (+)
C3H/HeJ MGP_C3HHeJ_G0030126
 protein coding gene Chr6:1499824-1512877 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030867
 protein coding gene Chr6:1586709-1601400 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028078
 protein coding gene Chr6:1226192-1239176 (+)
CAST/EiJ MGP_CASTEiJ_G0029527
 protein coding gene Chr6:1492246-1506957 (+)
CBA/J MGP_CBAJ_G0030104
 protein coding gene Chr6:1606789-1623070 (+)
DBA/2J MGP_DBA2J_G0030248
 protein coding gene Chr6:1446981-1463966 (+)
FVB/NJ MGP_FVBNJ_G0030202
 protein coding gene Chr6:1454082-1467919 (+)
LP/J MGP_LPJ_G0030335
 protein coding gene Chr6:1504640-1518415 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030238
 protein coding gene Chr6:1709579-1723635 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030897
 protein coding gene Chr6:1460682-1477268 (+)
PWK/PhJ MGP_PWKPhJ_G0029242
 protein coding gene Chr6:1389037-1402574 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029078
 protein coding gene Chr6:1542132-1555665 (+)
WSB/EiJ MGP_WSBEiJ_G0029604
 protein coding gene Chr6:1478352-1494089 (+)



Homology
more
  • Human Ortholog
    PEG10, paternally expressed 10
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEG10, paternally expressed 10
  • Synonyms
    EDR, HB-1, Mar2, Mart2, MEF3L, RGAG3, RTL2, SIRH1
  • Links
    NCBI Gene ID: 23089
    neXtProt AC: NX_Q86TG7
    UniProt: Q86TG7

  • Chr Location
    7q21.3; chr7:94656325-94669695 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous mice with a paternally inherited null allele display embryonic lethality during organogenesis with abnormal placental development. Heterozygous mice with a maternally inherited null allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    91
  • cDNA Data
    48
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170676 NCBI Gene Model | MGI Sequence Detail 13212 C57BL/6J ±  kb
    transcript NM_001040611 RefSeq | MGI Sequence Detail 6677 ZRU/MplStud  
    polypeptide Q7TN75 UniProt | EBI | MGI Sequence Detail 958 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 48
      Primer pair 9
      Other 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1353625
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 28
      Gene Ontology 8
      Phenotypes 5
    • Earliest
      J:72470 Steplewski A, et al., MyEF-3, a developmentally controlled brain-derived nuclear protein which specifically interacts with myelin basic protein proximal regulatory sequences. Biochem Biophys Res Commun. 1998 Feb 4;243(1):295-301
    • Latest
      J:357552 McRae HM, et al., Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Borjeson-Forssman-Lehmann intellectual disability syndrome. PLoS Genet. 2024 Oct;20(10):e1011428
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory