Rln3 MGI Mouse Gene Detail - MGI:2158015

Symbol

Rln3
Name

relaxin 3
Synonyms

M3

Feature Type

protein coding gene
IDs

MGI:2158015
NCBI Gene: 212108
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:84769696-84771608 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 40.26 cM
Mapping Data

1 experiment

SNPs within 2kb

133 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2158015	protein coding gene	Chr8:84769558-84771629 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033850	protein coding gene	Chr8:84908908-84910988 (-)
A/J	MGP_AJ_G0033833	protein coding gene	Chr8:81584617-81586696 (-)
AKR/J	MGP_AKRJ_G0033759	protein coding gene	Chr8:83997266-83999340 (-)
BALB/cJ	MGP_BALBcJ_G0033826	protein coding gene	Chr8:81691535-81693615 (-)
C3H/HeJ	MGP_C3HHeJ_G0033536	protein coding gene	Chr8:84602535-84604614 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034346	protein coding gene	Chr8:88164685-88166756 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031288	protein coding gene	Chr8:75384356-75386434 (-)
CAST/EiJ	MGP_CASTEiJ_G0032866	protein coding gene	Chr8:84024454-84026531 (-)
CBA/J	MGP_CBAJ_G0033512	protein coding gene	Chr8:91286262-91288341 (-)
DBA/2J	MGP_DBA2J_G0033666	protein coding gene	Chr8:81221251-81223331 (-)
FVB/NJ	MGP_FVBNJ_G0033613	protein coding gene	Chr8:80143067-80145138 (-)
LP/J	MGP_LPJ_G0033757	protein coding gene	Chr8:85020090-85022170 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033655	protein coding gene	Chr8:93784126-93786197 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034363	protein coding gene	Chr8:83968012-83970083 (-)
PWK/PhJ	MGP_PWKPhJ_G0032570	protein coding gene	Chr8:80445899-80448023 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032406	protein coding gene	Chr8:82782800-82784867 (-)
WSB/EiJ	MGP_WSBEiJ_G0032979	protein coding gene	Chr8:84386361-84388432 (-)

Human Ortholog

RLN3, relaxin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RLN3, relaxin 3
Synonyms

H3, insl7, RXN3, ZINS4
Links

HGNC:17135

NCBI Gene ID: 117579

neXtProt AC: NX_Q8WXF3

UniProt: Q8WXF3
Chr Location

19p13.12; chr19:14028148-14031551 (+) GRCh38

MGI Vertebrate Homology

Rln3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RLN3
Gene Tree

Rln3

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Phenotype Summary

22 phenotypes from 3 alleles in 3 genetic backgrounds
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Rln3
Incidental Mutations

CvDC
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit abnormal body weight regulation, actvity levels, social investigation and behavioral despair.

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All GO Annotations

6
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

42
cDNA Data

6
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rln3

ZFIN rln3a, rln3b

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All Sequences

26
RefSeq

2
UniProt

1
CCDS

CCDS22466.1

Ensembl

ENSMUSG00000045232 (Evidence)
NCBI Gene

212108

			Length	Strain/Species	Flank
genomic	212108	NCBI Gene Model \| MGI Sequence Detail	1913	C57BL/6J	± kb
transcript	NM_173184	RefSeq \| MGI Sequence Detail	475	Not Specified
polypeptide	Q8CHK2	UniProt \| EBI \| MGI Sequence Detail	141	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014035 relaxin-3

(term hierarchy)
InterPro Domains

IPR022353 Insulin, conserved site

IPR022352 Insulin family

IPR016179 Insulin-like

IPR051777 Insulin-like_neuropeptide_ligands

IPR036438 Insulin-like superfamily

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All nucleic 6

cDNA 6

Microarray probesets 1

Summaries

All 72

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 47
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:354346 Wang Q, et al., Hypothalamic-hindbrain circuit for consumption-induced fear regulation. Nat Commun. 2024 Sep 4;15(1):7728

TSS for Rln3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82061	Chr8:84771611-84771624 (-)	-10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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