Acot8 MGI Mouse Gene Detail - MGI:2158201

Symbol

Acot8
Name

acyl-CoA thioesterase 8
Synonyms

Pte1, PTE-2

Feature Type

protein coding gene
IDs

MGI:2158201
NCBI Gene: 170789
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:164634685-164646802 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.27 cM, cytoband H3
Mapping Data

1 experiment

SNPs within 2kb

324 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2158201	protein coding gene	Chr2:164634685-164662132 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026874	protein coding gene	Chr2:170293869-170307373 (-)
A/J	MGP_AJ_G0026841	protein coding gene	Chr2:163331325-163343897 (-)
AKR/J	MGP_AKRJ_G0026812	protein coding gene	Chr2:168185575-168218938 (-)
BALB/cJ	MGP_BALBcJ_G0026850	protein coding gene	Chr2:163690806-163703155 (-)
C3H/HeJ	MGP_C3HHeJ_G0026592	protein coding gene	Chr2:168549260-168564388 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027297	protein coding gene	Chr2:175222666-175238297 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024668	protein coding gene	Chr2:156737451-156749176 (-)
CAST/EiJ	MGP_CASTEiJ_G0026050	protein coding gene	Chr2:168966670-168978095 (-)
CBA/J	MGP_CBAJ_G0026569	protein coding gene	Chr2:181580476-181597940 (-)
DBA/2J	MGP_DBA2J_G0026707	protein coding gene	Chr2:162497012-162509219 (-)
FVB/NJ	MGP_FVBNJ_G0026673	protein coding gene	Chr2:160917408-160930173 (-)
LP/J	MGP_LPJ_G0026809	protein coding gene	Chr2:170353288-170365251 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026692	protein coding gene	Chr2:185149235-185162166 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027354	protein coding gene	Chr2:168092618-168105879 (-)
PWK/PhJ	MGP_PWKPhJ_G0025787	protein coding gene	Chr2:162097677-162110279 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025588	protein coding gene	Chr2:166988798-167002422 (-)
WSB/EiJ	MGP_WSBEiJ_G0026123	protein coding gene	Chr2:168973667-168985739 (-)

Human Ortholog

ACOT8, acyl-CoA thioesterase 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOT8, acyl-CoA thioesterase 8
Synonyms

hACTE-III, HNAACTE, hTE, NAP1, PTE-1, PTE1, PTE-2, PTE2
Links

HGNC:15919

NCBI Gene ID: 10005

neXtProt AC: NX_O14734

UniProt: O14734
Chr Location

20q13.12; chr20:45841721-45857405 (-) GRCh38

MGI Vertebrate Homology

Acot8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACOT8
Gene Tree

Acot8

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

4
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

38
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

35
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acot8

ZFIN acot8

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All Sequences

57
RefSeq

15
UniProt

4
CCDS

CCDS17057.1, CCDS89580.1

Ensembl

ENSMUSG00000017307 (Evidence)
NCBI Gene

170789

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017307	Ensembl Gene Model \| MGI Sequence Detail	12118	C57BL/6J	± kb
transcript	ENSMUST00000103094	Ensembl \| MGI Sequence Detail	1152	Not Applicable
polypeptide	ENSMUSP00000099383	Ensembl \| MGI Sequence Detail	320	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003640 acyl-coenzyme A thioesterase 8

(term hierarchy)
EC

3.1.2.1, 3.1.2.11, 3.1.2.2, 3.1.2.27, 3.1.2.3, 3.1.2.5
InterPro Domains

IPR003703 Acyl-CoA thioesterase

IPR042171 Acyl-CoA thioesterase, double hotdog domain

IPR025652 Acyl-CoA thioesterase II domain

IPR049450 Acyl-CoA thioesterase-like, C-terminal domain

IPR049449 Acyl-CoA thioesterase-like, N-terminal HotDog domain

IPR029069 HotDog domain superfamily
GlyGen

P58137 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 35

cDNA 35

Microarray probesets 5

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 10
Earliest

J:73690 Hunt MC, et al., Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism. J Biol Chem. 2002 Jan 11;277(2):1128-38
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acot8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27542	Chr2:164647114-164647123 (-)	-317 bp
Tssr27541	Chr2:164646796-164646814 (-)	-3 bp
Tssr27540	Chr2:164646768-164646783 (-)	26 bp
Tssr27539	Chr2:164646744-164646757 (-)	51 bp
Tssr27538	Chr2:164646606-164646653 (-)	172 bp
Tssr27537	Chr2:164645547-164645551 (-)	1,253 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24