Mbd3l2 Gene Detail

Summary

• Symbol
  Mbd3l2
• Name
  methyl-CpG binding domain protein 3-like 2

• Feature Type
  protein coding gene
• IDs
  MGI:2158460
  NCBI Gene: 234988
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr9:18341950-18357612 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 7.05 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  586 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2158460	protein coding gene	Chr9:18341911-18357612 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034375	protein coding gene	Chr9:15472713-15475569 (+)
A/J	MGP_AJ_G0034354	protein coding gene	Chr9:15341449-15344305 (+)
AKR/J	MGP_AKRJ_G0034282	protein coding gene	Chr9:15483458-15486314 (+)
BALB/cJ	MGP_BALBcJ_G0034346	protein coding gene	Chr9:15168365-15171207 (+)
C3H/HeJ	MGP_C3HHeJ_G0034059	protein coding gene	Chr9:15772874-15775730 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034869	protein coding gene	Chr9:16055144-16058000 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031806	protein coding gene	Chr9:14423695-14428582 (+)
CAST/EiJ	MGP_CASTEiJ_G0033385	protein coding gene	Chr9:15610217-15613063 (+)
CBA/J	MGP_CBAJ_G0034032	protein coding gene	Chr9:16732546-16735402 (+)
DBA/2J	MGP_DBA2J_G0034189	protein coding gene	Chr9:15194949-15197805 (+)
FVB/NJ	MGP_FVBNJ_G0034133	protein coding gene	Chr9:14753057-14755913 (+)
LP/J	MGP_LPJ_G0034275	protein coding gene	Chr9:15691103-15693959 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034178	protein coding gene	Chr9:17882297-17885153 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034888	protein coding gene	Chr9:15476930-15479786 (+)
PWK/PhJ	MGP_PWKPhJ_G0033091	protein coding gene	Chr9:15251120-15253975 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032926	protein coding gene	Chr9:15516213-15519084 (+)
WSB/EiJ	MGP_WSBEiJ_G0033502	protein coding gene	Chr9:15271753-15274609 (+)

Homology

• Human Ortholog
  MBD3L2, methyl-CpG binding domain protein 3 like 2

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MBD3L2, methyl-CpG binding domain protein 3 like 2
  
• Links
  HGNC:18532

  NCBI Gene ID: 125997

  neXtProt AC: NX_Q8NHZ7

  UniProt: Q8NHZ7

  
  
• Chr Location
  19p13.2; chr19:7049321-7051735 (+)  GRCh38

---

• Human Ortholog
  MBD3L2B, methyl-CpG binding domain protein 3 like 2B
  
• Links
  HGNC:53435

  NCBI Gene ID: 729458

  UniProt: A0A1B0GVZ6

  
  
• Chr Location
  19p13.2; chr19:7018969-7021431 (-)  GRCh38

---

• Human Ortholog
  MBD3L3, methyl-CpG binding domain protein 3 like 3
  
• Links
  HGNC:37205

  NCBI Gene ID: 653657

  neXtProt AC: NX_A6NE82

  UniProt: A6NE82

  
  
• Chr Location
  19p13.2; chr19:7056207-7069665 (-)  GRCh38

---

• Human Ortholog
  MBD3L4, methyl-CpG binding domain protein 3 like 4
  
• Links
  HGNC:37206

  NCBI Gene ID: 653656

  neXtProt AC: NX_A6NDZ8

  UniProt: A6NDZ8

  
  
• Chr Location
  19p13.2; chr19:7037749-7040179 (-)  GRCh38

---

• Human Ortholog
  MBD3L5, methyl-CpG binding domain protein 3 like 5
  
• Links
  HGNC:37204

  NCBI Gene ID: 284428

  neXtProt AC: NX_A6NJ08

  UniProt: A6NJ08

  
  
• Chr Location
  19p13.2; chr19:7030578-7033011 (+)  GRCh38

---

• MGI Vertebrate Homology
  Mbd3l2 stringent orthology
  5 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: MBD3L2, MBD3L2B, MBD3L3, MBD3L4, MBD3L5
• Gene Tree
  Mbd3l2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  3 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  1
• Targeted
  2
• Find Mice (IMSR)
  15 strains or lines available

Homozygous null mice are viable and fertile.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  5
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  17

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  38
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS22844.1

• Ensembl
  ENSMUSG00000047508 (Evidence)
• NCBI Gene
  234988

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000047508	Ensembl Gene Model | MGI Sequence Detail	15663	C57BL/6J
transcript	ENSMUST00000051008	Ensembl | MGI Sequence Detail	2075	Not Applicable
polypeptide	ENSMUSP00000054515	Ensembl | MGI Sequence Detail	228	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region
  IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain

Molecular
Reagents

• All nucleic 17

  cDNA 17

  
  

  Microarray probesets 5

References

• Summaries
  All 24

  Gene Ontology 2

  Phenotypes 3
• Earliest
  J:80802 Jiang CL, et al., MBD3L1 and MBD3L2, Two New Proteins Homologous to the Methyl-CpG-Binding Proteins MBD2 and MBD3: Characterization of MBD3L1 as a Testis-Specific Transcriptional Repressor. Genomics. 2002 Dec;80(6):621-9
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582