Il17rc MGI Mouse Gene Detail - MGI:2159336

Symbol

Il17rc
Name

interleukin 17 receptor C
Synonyms

1110025H02Rik, Il17rl, IL17-RL

Feature Type

protein coding gene
IDs

MGI:2159336
NCBI Gene: 171095
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:113448416-113460124 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 52.77 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

353 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159336	protein coding gene	Chr6:113448388-113460124 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031126	protein coding gene	Chr6:115992858-116004614 (+)
A/J	MGP_AJ_G0031095	protein coding gene	Chr6:111548477-111560194 (+)
AKR/J	MGP_AKRJ_G0031026	protein coding gene	Chr6:114542358-114554061 (+)
BALB/cJ	MGP_BALBcJ_G0031106	protein coding gene	Chr6:111494486-111506218 (+)
C3H/HeJ	MGP_C3HHeJ_G0030602	protein coding gene	Chr6:69742684-69755734 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031565	protein coding gene	Chr6:118995998-119008822 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028729	protein coding gene	Chr6:108576421-108588115 (+)
CAST/EiJ	MGP_CASTEiJ_G0030213	protein coding gene	Chr6:114988291-115000036 (+)
CBA/J	MGP_CBAJ_G0030792	protein coding gene	Chr6:123691362-123703050 (+)
DBA/2J	MGP_DBA2J_G0030945	protein coding gene	Chr6:110627885-110639563 (+)
FVB/NJ	MGP_FVBNJ_G0030899	protein coding gene	Chr6:109629986-109641667 (+)
LP/J	MGP_LPJ_G0031025	protein coding gene	Chr6:116028056-116039908 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030933	protein coding gene	Chr6:127955778-127967459 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031592	protein coding gene	Chr6:114556713-114568392 (+)
PWK/PhJ	MGP_PWKPhJ_G0029929	protein coding gene	Chr6:109584102-109595927 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029757	protein coding gene	Chr6:113375241-113386958 (+)
WSB/EiJ	MGP_WSBEiJ_G0030297	protein coding gene	Chr6:114931333-114943018 (+)

Human Ortholog

IL17RC, interleukin 17 receptor C

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL17RC, interleukin 17 receptor C
Synonyms

CANDF9, IL17-RL, IL17RL
Links

HGNC:18358

NCBI Gene ID: 84818

neXtProt AC: NX_Q8NAC3

UniProt: Q8NAC3
Chr Location

3p25.3; chr3:9917074-9933630 (+) GRCh38

MGI Vertebrate Homology

Il17rc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IL17RC
Gene Tree

Il17rc

Diseases

1 with human IL17RC associations

				Human Disease	Mouse Models
				chronic mucocutaneous candidiasis IDs chronic mucocutaneous candidiasis DOID:2058 DOID:2056 MESH:D002178 NCI:C34444 OMIM:114580 OMIM:212050 OMIM:607644 OMIM:613108 OMIM:613956 OMIM:614162 OMIM:615527 OMIM:616445 ORDO:1334 UMLS_CUI:C0006845

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

1
Spontaneous

1
Targeted

6
Genomic Mutations

1 involving Il17rc
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele exhibit increased interleukin-17 secretion, reduced chemokine expression, and decreased susceptibility to experimental autoimmune encephalomyelitis.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

16
cDNA Data

43
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il17rc

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All Sequences

56
RefSeq

13
UniProt

5
CCDS

CCDS20422.1

Ensembl

ENSMUSG00000030281 (Evidence)
NCBI Gene

171095

			Length	Strain/Species	Flank
genomic	171095	NCBI Gene Model \| MGI Sequence Detail	11709	C57BL/6J	± kb
transcript	NM_178942	RefSeq \| MGI Sequence Detail	2369	Not Specified
polypeptide	Q8K4C2	UniProt \| EBI \| MGI Sequence Detail	698	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008983 interleukin-17 receptor C

(term hierarchy)
InterPro Domains

IPR027841 Interleukin-17 receptor C/E, N-terminal

IPR039465 Interleukin-17 receptor-like

IPR013568 SEFIR domain
GlyGen

Q8K4C2 5 sites

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All nucleic 45

cDNA 45

Microarray probesets 3

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MGI:1923564

Summaries

All 67

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 36
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352224 Chandra V, et al., Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation. Cancer Cell. 2024 Jan 8;42(1):85-100.e6

TSS for Il17rc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58215	Chr6:113448425-113448436 (+)	15 bp
Tssr58216	Chr6:113448442-113448474 (+)	42 bp
Tssr58217	Chr6:113448476-113448501 (+)	73 bp
Tssr58218	Chr6:113449220-113449230 (+)	809 bp
Tssr58219	Chr6:113449237-113449252 (+)	829 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24