About   Help   FAQ
Pja2 Gene Detail
Summary
  • Symbol
    Pja2
  • Name
    praja ring finger ubiquitin ligase 2
  • Synonyms
    mKIAA0438, Neurodap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159342
    NCBI Gene: 224938
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:64588001-64638878 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 33.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159342
 protein coding gene Chr17:64588000-64638911 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023973
 protein coding gene Chr17:66353562-66405425 (-)
A/J MGP_AJ_G0023931
 protein coding gene Chr17:64399142-64449893 (-)
AKR/J MGP_AKRJ_G0023900
 protein coding gene Chr17:65271884-65322655 (-)
BALB/cJ MGP_BALBcJ_G0023932
 protein coding gene Chr17:64324459-64375627 (-)
C3H/HeJ MGP_C3HHeJ_G0023696
 protein coding gene Chr17:66139827-66191662 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024378
 protein coding gene Chr17:68932398-68986267 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021824
 protein coding gene Chr17:60501789-60553501 (-)
CAST/EiJ MGP_CASTEiJ_G0023178
 protein coding gene Chr17:66491051-66553552 (-)
CBA/J MGP_CBAJ_G0023672
 protein coding gene Chr17:71695161-71747179 (-)
DBA/2J MGP_DBA2J_G0023800
 protein coding gene Chr17:63150542-63201880 (-)
FVB/NJ MGP_FVBNJ_G0023766
 protein coding gene Chr17:62622464-62677904 (-)
LP/J MGP_LPJ_G0023882
 protein coding gene Chr17:67102937-67156167 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023794
 protein coding gene Chr17:71784255-71840720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024422
 protein coding gene Chr17:65723192-65775675 (-)
PWK/PhJ MGP_PWKPhJ_G0022924
 protein coding gene Chr17:62404851-62459469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022735
 protein coding gene Chr17:62412585-62472756 (-)
WSB/EiJ MGP_WSBEiJ_G0023244
 protein coding gene Chr17:66415791-66471143 (-)



Homology
more
  • Human Ortholog
    PJA2, praja ring finger ubiquitin ligase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PJA2, praja ring finger ubiquitin ligase 2
  • Synonyms
    Neurodap1, RNF131
  • Links
    NCBI Gene ID: 9867
    neXtProt AC: NX_O43164
    UniProt: O43164

  • Chr Location
    5q21.3; chr5:109334713-109409974 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit epithelial and vascular alterations in kidney tissue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    11
  • cDNA Data
    147
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224938 NCBI Gene Model | MGI Sequence Detail 50878 C57BL/6J ±  kb
    transcript NM_001025309 RefSeq | MGI Sequence Detail 4706 Not Specified  
    polypeptide Q80U04 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      cDNA 147
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2146857, MGI:2146949, MGI:2652263
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:77266 Sasaki A, et al., A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. J Biol Chem. 2002 Jun 21;277(25):22541-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory