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Tmie Gene Detail
Summary
  • Symbol
    Tmie
  • Name
    transmembrane inner ear
  • Synonyms
    5131400L21Rik, Mm.87012
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159400
    NCBI Gene: 20776
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:110694755-110709141 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 60.79 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159400
 protein coding gene Chr9:110694755-110709181 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035362
 protein coding gene Chr9:113054783-113071600 (-)
A/J MGP_AJ_G0035343
 protein coding gene Chr9:108929953-108944076 (-)
AKR/J MGP_AKRJ_G0035274
 protein coding gene Chr9:111637706-111651903 (-)
BALB/cJ MGP_BALBcJ_G0035338
 protein coding gene Chr9:108690372-108704563 (-)
C3H/HeJ MGP_C3HHeJ_G0035046
 protein coding gene Chr9:112147290-112161461 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035860
 protein coding gene Chr9:116150742-116168689 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032746
 protein coding gene Chr9:106148863-106163659 (-)
CAST/EiJ MGP_CASTEiJ_G0034352
 protein coding gene Chr9:111937895-111954438 (-)
CBA/J MGP_CBAJ_G0035013
 protein coding gene Chr9:120449241-120466758 (-)
DBA/2J MGP_DBA2J_G0035172
 protein coding gene Chr9:108392318-108406530 (-)
FVB/NJ MGP_FVBNJ_G0035119
 protein coding gene Chr9:107229377-107245343 (-)
LP/J MGP_LPJ_G0035251
 protein coding gene Chr9:113344793-113360762 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035159
 protein coding gene Chr9:121769755-121782698 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035880
 protein coding gene Chr9:111987754-112001226 (-)
PWK/PhJ MGP_PWKPhJ_G0034059
 protein coding gene Chr9:108640880-108655601 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033894
 protein coding gene Chr9:112066168-112080342 (-)
WSB/EiJ MGP_WSBEiJ_G0034473
 protein coding gene Chr9:111856607-111871236 (-)



Homology
more
  • Human Ortholog
    TMIE, transmembrane inner ear
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMIE, transmembrane inner ear
  • Synonyms
    DFNB6
  • Links
    NCBI Gene ID: 259236
    neXtProt AC: NX_Q8NEW7
    UniProt: Q8NEW7

  • Chr Location
    3p21.31; chr3:46693778-46710886 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TMIE associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene cause circling behavior and deafness in homozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20776 NCBI Gene Model | MGI Sequence Detail 14387 C57BL/6J ±  kb
transcript NM_146260 RefSeq | MGI Sequence Detail 2786 ZRU/MplStud  
polypeptide Q8K467 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14553, MGI:2443547, MGI:98395
References
more
  • Summaries
    All 62
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 38
  • Earliest
    J:13132 DEOL MS, et al., The spinner mouse. J Hered. 1962 May-Jun;53:133-6
  • Latest
    J:354230 Wang P, et al., LOXHD1 is indispensable for maintaining TMC1 auditory mechanosensitive channels at the site of force transmission. Nat Commun. 2024 Sep 10;15(1):7865
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory