Kcnh7 MGI Mouse Gene Detail - MGI:2159566 - potassium voltage-gated channel, subfamily H (eag-related), member 7

Symbol

Kcnh7
Name

potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms

9330137I11Rik, erg3, Kv11.3

Feature Type

protein coding gene
IDs

MGI:2159566
NCBI Gene: 170738
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:62524428-63014980 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 36.50 cM
Mapping Data

1 experiment

SNPs within 2kb

13659 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159566	protein coding gene	Chr2:62523758-63014980 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025774	protein coding gene	Chr2:62396166-62907531 (-)
A/J	MGP_AJ_G0025750	protein coding gene	Chr2:60002788-60499384 (-)
AKR/J	MGP_AKRJ_G0025720	protein coding gene	Chr2:61606189-62116040 (-)
BALB/cJ	MGP_BALBcJ_G0025745	protein coding gene	Chr2:60117814-60638515 (-)
C3H/HeJ	MGP_C3HHeJ_G0025506	protein coding gene	Chr2:61718584-62232575 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026192	protein coding gene	Chr2:64229681-64764603 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023596	protein coding gene	Chr2:57517562-57980647 (-)
CAST/EiJ	MGP_CASTEiJ_G0024970	protein coding gene	Chr2:61797867-62314274 (-)
CBA/J	MGP_CBAJ_G0025486	protein coding gene	Chr2:66663239-67214774 (-)
DBA/2J	MGP_DBA2J_G0025617	protein coding gene	Chr2:59585373-60082563 (-)
FVB/NJ	MGP_FVBNJ_G0025579	protein coding gene	Chr2:59104873-59593411 (-)
LP/J	MGP_LPJ_G0025705	protein coding gene	Chr2:62221152-62739471 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025610	protein coding gene	Chr2:68354592-68995439 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026249	protein coding gene	Chr2:61680770-62184398 (-)
PWK/PhJ	MGP_PWKPhJ_G0024711	protein coding gene	Chr2:59457199-59947882 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024518	protein coding gene	Chr2:61827558-62332799 (-)
WSB/EiJ	MGP_WSBEiJ_G0025038	protein coding gene	Chr2:62004751-62515469 (-)

Human Ortholog

KCNH7, potassium voltage-gated channel subfamily H member 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNH7, potassium voltage-gated channel subfamily H member 7
Synonyms

ERG3, HERG3, Kv11.3
Links

HGNC:18863

NCBI Gene ID: 90134

neXtProt AC: NX_Q9NS40

UniProt: Q9NS40
Chr Location

2q24.2; chr2:162371407-162838767 (-) GRCh38

MGI Vertebrate Homology

Kcnh7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCNH7
Gene Tree

Kcnh7

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

2
Genomic Mutations

1 involving Kcnh7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

57
cDNA Data

7
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnh7

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All Sequences

68
RefSeq

34
UniProt

3
CCDS

CCDS38128.1

Ensembl

ENSMUSG00000059742 (Evidence)
NCBI Gene

170738

			Length	Strain/Species	Flank
genomic	170738	NCBI Gene Model \| MGI Sequence Detail	490553	C57BL/6J	± kb
transcript	NM_133207	RefSeq \| MGI Sequence Detail	3798	Not Specified
polypeptide	Q9ER47	UniProt \| EBI \| MGI Sequence Detail	1195	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000000796 voltage-gated potassium channel KCNH7

(term hierarchy)
InterPro Domains

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR005821 Ion transport domain

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG

IPR003967 Potassium channel, voltage-dependent, ERG

IPR014710 RmlC-like jelly roll fold

IPR050818 Voltage-gated potassium channel family H
GlyGen

Q9ER47 1 site, 1 N-linked glycan (1 site)

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All nucleic 12

cDNA 7

Primer pair 3

Other 2

Microarray probesets 2

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MGI:2444334

Summaries

All 41

Developmental Gene Expression 7

Gene Ontology 5

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:358013 Schwarz JR, et al., Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-a-go-go-related gene) K(+) channel subunits. Sci Adv. 2024 Oct 4;10(40):eadn6836

TSS for Kcnh7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24325	Chr2:63014898-63014910 (-)	76 bp
Tssr24324	Chr2:63014878-63014893 (-)	94 bp
Tssr24323	Chr2:63014802-63014813 (-)	172 bp
Tssr24322	Chr2:63014642-63014679 (-)	319 bp
Tssr24321	Chr2:63014597-63014636 (-)	363 bp
Tssr24320	Chr2:63014580-63014596 (-)	392 bp
Tssr24319	Chr2:63014528-63014539 (-)	446 bp
Tssr24318	Chr2:62954249-62954253 (-)	60,729 bp
Tssr24317	Chr2:62943467-62943477 (-)	71,508 bp
Tssr24316	Chr2:62918603-62918609 (-)	96,374 bp
Tssr24315	Chr2:62910447-62910455 (-)	104,529 bp
Tssr24314	Chr2:62631072-62631077 (-)	383,905 bp
Tssr24313	Chr2:62603754-62603757 (-)	411,224 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24