Il17rd MGI Mouse Gene Detail - MGI:2159727

Symbol

Il17rd
Name

interleukin 17 receptor D
Synonyms

2810004A10Rik, Sef, Sef-S

Feature Type

protein coding gene
IDs

MGI:2159727
NCBI Gene: 171463
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:26760990-26829243 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 16.09 cM
Mapping Data

4 experiments

SNPs within 2kb

1892 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159727	protein coding gene	Chr14:26760898-26829243 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021089	protein coding gene	Chr14:20038334-20112146 (+)
A/J	MGP_AJ_G0021038	protein coding gene	Chr14:19242885-19312953 (+)
AKR/J	MGP_AKRJ_G0021015	protein coding gene	Chr14:20297138-20372433 (+)
BALB/cJ	MGP_BALBcJ_G0021041	protein coding gene	Chr14:19360579-19429719 (+)
C3H/HeJ	MGP_C3HHeJ_G0020825	protein coding gene	Chr14:20145989-20223746 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021474	protein coding gene	Chr14:20867482-20938634 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019037	protein coding gene	Chr14:19376294-19444518 (+)
CAST/EiJ	MGP_CASTEiJ_G0020349	protein coding gene	Chr14:19779041-19857820 (+)
CBA/J	MGP_CBAJ_G0020791	protein coding gene	Chr14:21697701-21774094 (+)
DBA/2J	MGP_DBA2J_G0020914	protein coding gene	Chr14:19327343-19395838 (+)
FVB/NJ	MGP_FVBNJ_G0020897	protein coding gene	Chr14:19288242-19356678 (+)
LP/J	MGP_LPJ_G0020982	protein coding gene	Chr14:20330151-20407870 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020923	protein coding gene	Chr14:21065559-21139790 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021507	protein coding gene	Chr14:20060522-20131597 (+)
PWK/PhJ	MGP_PWKPhJ_G0020098	protein coding gene	Chr14:18725630-18802410 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019921	protein coding gene	Chr14:19554987-19627301 (+)
WSB/EiJ	MGP_WSBEiJ_G0020405	protein coding gene	Chr14:20098153-20169459 (+)

Human Ortholog

IL17RD, interleukin 17 receptor D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL17RD, interleukin 17 receptor D
Synonyms

HH18, IL-17RD, IL17RLM, SEF
Links

HGNC:17616

NCBI Gene ID: 54756

neXtProt AC: NX_Q8NFM7

UniProt: Q8NFM7
Chr Location

3p14.3; chr3:57089982-57170317 (-) GRCh38

MGI Vertebrate Homology

Il17rd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL17RD
Gene Tree

Il17rd

Diseases

1 with human IL17RD associations

				Human Disease	Mouse Models
				hypogonadotropic hypogonadism 18 with or without anosmia IDs hypogonadotropic hypogonadism 18 with or without anosmia DOID:0090076 ICD10CM:E23.0 OMIM:615267

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

86
Endonuclease-mediated

3
Gene trapped

78
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

85 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and show no obvious phenotype. A subset of mice homozygous for a gene-trapped allele display cochlear nucleus defects and abnormal auditory brainstem responses.

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

894
Tissues

81
cDNA Data

36
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IL17RD

Xenbase il17rd

ZFIN il17rd

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All Sequences

57
RefSeq

6
UniProt

6
CCDS

CCDS26885.1

Ensembl

ENSMUSG00000040717 (Evidence)
NCBI Gene

171463

			Length	Strain/Species	Flank
genomic	171463	NCBI Gene Model \| MGI Sequence Detail	68254	C57BL/6J	± kb
transcript	NM_134437	RefSeq \| MGI Sequence Detail	8188	C57BL/6
polypeptide	Q8JZL1	UniProt \| EBI \| MGI Sequence Detail	738	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008984 interleukin-17 receptor D

(term hierarchy)
InterPro Domains

IPR031951 Interleukin 17 receptor D, N-terminal

IPR039465 Interleukin-17 receptor-like

IPR013568 SEFIR domain

IPR013087 Zinc finger C2H2-type
GlyGen

Q8JZL1 8 sites, 4 N-linked glycans (4 sites)

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All nucleic 38

cDNA 37

Other 1

Microarray probesets 5

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MGI:1917183, MGI:2145635

Summaries

All 74

Developmental Gene Expression 16

Gene Ontology 7

Phenotypes 23
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Il17rd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124720	Chr14:26760945-26760950 (+)	-42 bp
Tssr124721	Chr14:26760952-26760965 (+)	-31 bp
Tssr124722	Chr14:26760971-26761007 (+)	-1 bp
Tssr124723	Chr14:26761023-26761034 (+)	39 bp
Tssr124724	Chr14:26789345-26789358 (+)	28,362 bp
Tssr124725	Chr14:26813729-26813733 (+)	52,741 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24