Slc26a6 MGI Mouse Gene Detail - MGI:2159728 - solute carrier family 26, member 6

Symbol

Slc26a6
Name

solute carrier family 26, member 6
Synonyms

B930010B04Rik, CFEX, Pat1

Feature Type

protein coding gene
IDs

MGI:2159728
NCBI Gene: 171429
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:108731239-108742117 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.63 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159728	protein coding gene	Chr9:108730482-108742117 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035315	protein coding gene	Chr9:110844257-110855748 (+)
A/J	MGP_AJ_G0035294	protein coding gene	Chr9:106779007-106790592 (+)
AKR/J	MGP_AKRJ_G0035226	protein coding gene	Chr9:109455624-109467151 (+)
BALB/cJ	MGP_BALBcJ_G0035288	protein coding gene	Chr9:106471282-106483232 (+)
C3H/HeJ	MGP_C3HHeJ_G0034998	protein coding gene	Chr9:109854682-109866006 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035808	protein coding gene	Chr9:113865506-113877086 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032706	protein coding gene	Chr9:104188771-104199965 (+)
CAST/EiJ	MGP_CASTEiJ_G0034309	protein coding gene	Chr9:109821222-109835953 (+)
CBA/J	MGP_CBAJ_G0034966	protein coding gene	Chr9:117887946-117903264 (+)
DBA/2J	MGP_DBA2J_G0035127	protein coding gene	Chr9:106232007-106243386 (+)
FVB/NJ	MGP_FVBNJ_G0035075	protein coding gene	Chr9:104999978-105059989 (+)
LP/J	MGP_LPJ_G0035203	protein coding gene	Chr9:111032936-111045799 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035114	protein coding gene	Chr9:119442350-119456617 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035829	protein coding gene	Chr9:109731209-109742793 (+)
PWK/PhJ	MGP_PWKPhJ_G0034016	protein coding gene	Chr9:106563663-106575412 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033851	protein coding gene	Chr9:109798780-109810227 (+)
WSB/EiJ	MGP_WSBEiJ_G0034430	protein coding gene	Chr9:109623646-109635227 (+)

Human Ortholog

SLC26A6, solute carrier family 26 member 6

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC26A6, solute carrier family 26 member 6
Links

HGNC:14472

NCBI Gene ID: 65010

neXtProt AC: NX_Q9BXS9

UniProt: Q9BXS9
Chr Location

3p21.31; chr3:48625723-48635493 (-) GRCh38

MGI Vertebrate Homology

Slc26a6 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: SLC26A6
Gene Tree

Slc26a6

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Phenotype Summary

7 phenotypes from 3 alleles in 2 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display abnormal proximal tubule and duodenal anion exchange, but are otherwise normal.

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All GO Annotations

98
GO References

29

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc26a6

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All Sequences

58
RefSeq

7
UniProt

4

Ensembl

ENSMUSG00000023259 (Evidence)
NCBI Gene

171429

			Length	Strain/Species	Flank
genomic	171429	NCBI Gene Model \| MGI Sequence Detail	10879	C57BL/6J	± kb
transcript	NM_134420	RefSeq \| MGI Sequence Detail	3308	C57BL/6
polypeptide	Q8CIW6	UniProt \| EBI \| MGI Sequence Detail	758	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015041 solute carrier family 26 member 6

(term hierarchy)
InterPro Domains

IPR001902 SLC26A/SulP transporter

IPR011547 SLC26A/SulP transporter domain

IPR002645 STAS domain

IPR036513 STAS domain superfamily

IPR018045 Sulphate anion transporter, conserved site
GlyGen

Q8CIW6 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 13

cDNA 13

Microarray probesets 3

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MGI:2443071

Summaries

All 75

Developmental Gene Expression 2

Gene Ontology 29

Phenotypes 35
Earliest

J:75064 Knauf F, et al., Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9425-30
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Slc26a6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87165	Chr9:108731223-108731264 (+)	5 bp
Tssr87166	Chr9:108731268-108731283 (+)	37 bp
Tssr87167	Chr9:108731288-108731309 (+)	60 bp
Tssr87168	Chr9:108731885-108731905 (+)	656 bp
Tssr87169	Chr9:108731910-108731937 (+)	685 bp
Tssr87170	Chr9:108732729-108732736 (+)	1,494 bp
Tssr87171	Chr9:108732813-108732847 (+)	1,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24