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Tlr8 Gene Detail
Summary
  • Symbol
    Tlr8
  • Name
    toll-like receptor 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176887
    NCBI Gene: 170744
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:166025692-166047325 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 78.29 cM, cytoband F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176887
 protein coding gene ChrX:166024119-166047325 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036270
 protein coding gene ChrX:165407282-165425812 (-)
A/J MGP_AJ_G0036239
 protein coding gene ChrX:164552360-164570503 (-)
AKR/J MGP_AKRJ_G0036169
 protein coding gene ChrX:169835309-169850731 (-)
BALB/cJ MGP_BALBcJ_G0036234
 protein coding gene ChrX:162498352-162513796 (-)
C3H/HeJ MGP_C3HHeJ_G0035941
 protein coding gene ChrX:165712145-165730863 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036757
 protein coding gene ChrX:170208669-170226479 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033577
 protein coding gene ChrX:155367947-155383432 (-)
CAST/EiJ MGP_CASTEiJ_G0035228
 protein coding gene ChrX:144600497-144620776 (-)
CBA/J MGP_CBAJ_G0035915
 protein coding gene ChrX:175175589-175193501 (-)
DBA/2J MGP_DBA2J_G0036081
 protein coding gene ChrX:163361809-163382242 (-)
FVB/NJ MGP_FVBNJ_G0036013
 protein coding gene ChrX:162497698-162518442 (-)
LP/J MGP_LPJ_G0036166
 protein coding gene ChrX:166492776-166507815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036045
 protein coding gene ChrX:183862890-183884600 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036796
 protein coding gene ChrX:164865199-164886730 (-)
PWK/PhJ MGP_PWKPhJ_G0034927
 protein coding gene ChrX:141332571-141347802 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034746
 protein coding gene ChrX:145141396-145155279 (-)
WSB/EiJ MGP_WSBEiJ_G0035364
 protein coding gene ChrX:162713683-162732446 (-)



Homology
more
  • Human Ortholog
    TLR8, toll like receptor 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR8, toll like receptor 8
  • Synonyms
    CD288, hTLR8, IMD98, TLR-8
  • Links
    NCBI Gene ID: 51311
    neXtProt AC: NX_Q9NR97
    UniProt: Q9NR97

  • Chr Location
    Xp22.2; chrX:12906620-12923169 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TLR8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased anti-nuclear antigen antibodies, altered immunoglobulin levels, decreased marginal zone, B-1a, and B-1b cells, splenomegaly, and glomerulonephritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    10
  • cDNA Data
    5
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040522 Ensembl Gene Model | MGI Sequence Detail 21634 C57BL/6J ±  kb
    transcript ENSMUST00000112170 Ensembl | MGI Sequence Detail 3431 Not Applicable  
    polypeptide ENSMUSP00000107793 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001159 Toll-like receptor 8
      (term hierarchy)
    • InterPro Domains
      IPR026906 BspA-type LRR region
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    • GlyGen
      P58682 22 sites, 2 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:114769 Jurk M, et al., Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol. 2002 Jun;3(6):499
    • Latest
      J:312592 Wang Y, et al., TLR7 Signaling Drives the Development of Sjogren's Syndrome. Front Immunol. 2021;12:676010
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory