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Bco2 Gene Detail
Summary
  • Symbol
    Bco2
  • Name
    beta-carotene oxygenase 2
  • Synonyms
    Bcdo2, Bcmo2, B-diox-II, beta-diox-II, CMO2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177469
    NCBI Gene: 170752
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50444387-50466481 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.74 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    496 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177469
 protein coding gene Chr9:50444387-50466513 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034778
 protein coding gene Chr9:49423457-49446695 (-)
A/J MGP_AJ_G0034759
 protein coding gene Chr9:47914211-47937881 (-)
AKR/J MGP_AKRJ_G0034687
 protein coding gene Chr9:48927351-48948787 (-)
BALB/cJ MGP_BALBcJ_G0034751
 protein coding gene Chr9:47643049-47663988 (-)
C3H/HeJ MGP_C3HHeJ_G0034461
 protein coding gene Chr9:49410371-49431850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035271
 protein coding gene Chr9:50803891-50825065 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032184
 protein coding gene Chr9:47385478-47405986 (-)
CAST/EiJ MGP_CASTEiJ_G0033783
 protein coding gene Chr9:49358595-49381335 (-)
CBA/J MGP_CBAJ_G0034433
 protein coding gene Chr9:52611395-52631149 (-)
DBA/2J MGP_DBA2J_G0034592
 protein coding gene Chr9:47778790-47800751 (-)
FVB/NJ MGP_FVBNJ_G0034533
 protein coding gene Chr9:46998022-47017841 (-)
LP/J MGP_LPJ_G0034673
 protein coding gene Chr9:49784908-49804713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034577
 protein coding gene Chr9:54213946-54237146 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035292
 protein coding gene Chr9:48904844-48926705 (-)
PWK/PhJ MGP_PWKPhJ_G0033488
 protein coding gene Chr9:47755976-47778328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033323
 protein coding gene Chr9:49216167-49239329 (-)
WSB/EiJ MGP_WSBEiJ_G0033896
 protein coding gene Chr9:48906558-48926902 (-)



Homology
more
  • Human Ortholog
    BCO2, beta-carotene oxygenase 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCO2, beta-carotene oxygenase 2
  • Synonyms
    BCDO2, B-DIOX-II
  • Links
    NCBI Gene ID: 83875
    neXtProt AC: NX_Q9BYV7
    UniProt: Q9BYV7

  • Chr Location
    11q23.1; chr11:112175510-112224699 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased spleen weight, decreased testis and seminal vesicle weight, and increased tissue lycopene and beta-carotene levels when fed diets containing tomato powder or lycopene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    14
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032066 Ensembl Gene Model | MGI Sequence Detail 22095 C57BL/6J ±  kb
    transcript ENSMUST00000119103 Ensembl | MGI Sequence Detail 2118 Not Applicable  
    polypeptide ENSMUSP00000112727 Ensembl | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:74948 Kiefer C, et al., Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J Biol Chem. 2001 Apr 27;276(17):14110-6
    • Latest
      J:353895 Thomas LD, et al., Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid research. Mol Metab. 2023 May 22;73:101742
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory