Tchh Gene Detail

Summary

• Symbol
  Tchh
• Name
  trichohyalin
• Synonyms
  AHF, Thh

• Feature Type
  protein coding gene
• IDs
  MGI:2177944
  NCBI Gene: 99681
• Alliance
  gene page
• Transcription Start Sites
  69 TSS

Location &
Maps

• Sequence Map
  Chr3:93349637-93356384 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 40.51 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  186 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2177944	protein coding gene	Chr3:93348071-93356384 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027534	protein coding gene	Chr3:93930662-93939232 (+)
A/J	MGP_AJ_G0027499	protein coding gene	Chr3:91020212-91028722 (+)
AKR/J	MGP_AKRJ_G0027467	protein coding gene	Chr3:93120377-93127921 (+)
BALB/cJ	MGP_BALBcJ_G0027508	protein coding gene	Chr3:90775366-90779648 (+)
C3H/HeJ	MGP_C3HHeJ_G0027246	protein coding gene	Chr3:93334200-93342548 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027951	protein coding gene	Chr3:97504609-97513017 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025301	protein coding gene	Chr3:87617295-87625535 (+)
CAST/EiJ	MGP_CASTEiJ_G0026694	protein coding gene	Chr3:92779536-92787131 (+)
CBA/J	MGP_CBAJ_G0027222	protein coding gene	Chr3:100906104-100915175 (+)
DBA/2J	MGP_DBA2J_G0027359	protein coding gene	Chr3:90326405-90334658 (+)
FVB/NJ	MGP_FVBNJ_G0027328	protein coding gene	Chr3:88440706-88455741 (+)
LP/J	MGP_LPJ_G0027469	protein coding gene	Chr3:95182618-95191158 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027354	protein coding gene	Chr3:107149112-107157520 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028010	protein coding gene	Chr3:92833182-92847896 (+)
PWK/PhJ	MGP_PWKPhJ_G0026423	protein coding gene	Chr3:90187785-90195431 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026243	protein coding gene	Chr3:91196786-91204743 (+)
WSB/EiJ	MGP_WSBEiJ_G0026777	protein coding gene	Chr3:93225958-93233808 (+)

Homology

• Human Ortholog
  TCHH, trichohyalin

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TCHH, trichohyalin
  
• Synonyms
  THH, THL, TRHY, UHS3
• Links
  HGNC:11791

  NCBI Gene ID: 7062

  neXtProt AC: NX_Q07283

  UniProt: Q07283

  
  
• Chr Location
  1q21.3; chr1:152106317-152115444 (-)  GRCh38

---

• MGI Vertebrate Homology
  Tchh stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: TCHH
• Gene Tree
  Tchh
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  8 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Radiation induced
  1
• Genomic Mutations
  2 involving Tchh
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  60 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  2

Expression

• Assay Results
  724
• Tissues
  9
• cDNA Data
  20
• Literature Summary
  30

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS50980.1

• Ensembl
  ENSMUSG00000052415 (Evidence)
• NCBI Gene
  99681

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000052415	Ensembl Gene Model | MGI Sequence Detail	6748	C57BL/6J
transcript	ENSMUST00000064257	Ensembl | MGI Sequence Detail	5823	Not Applicable
polypeptide	ENSMUSP00000069525	Ensembl | MGI Sequence Detail	1599	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR018247 EF-Hand 1, calcium-binding site
  IPR002048 EF-hand domain
  IPR011992 EF-hand domain pair
  IPR034325 S-100
  IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
  IPR033200 Trichohyalin

Molecular
Reagents

• All nucleic 21

  cDNA 20

  Primer pair 1

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:2139762

References

• Summaries
  All 57

  Developmental Gene Expression 30

  Diseases 1

  Gene Ontology 2

  Phenotypes 8
• Earliest
  J:74930 Steinert PM, et al., Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes. J Biol Chem. 1998 May 8;273(19):11758-69
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tchh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30344	Chr3:93348068-93348071 (+)	-1,567 bp
Tssr30345	Chr3:93349678-93349696 (+)	50 bp
Tssr30346	Chr3:93349714-93349721 (+)	81 bp
Tssr960	Chr3:93350734-93350737 (+)	1,099 bp
Tssr30347	Chr3:93350758-93350780 (+)	1,132 bp
Tssr30348	Chr3:93350797-93350800 (+)	1,162 bp
Tssr30349	Chr3:93350803-93350812 (+)	1,171 bp
Tssr30350	Chr3:93350845-93350856 (+)	1,214 bp
Tssr30351	Chr3:93350876-93350880 (+)	1,241 bp
Tssr30352	Chr3:93350925-93350930 (+)	1,291 bp
Tssr30353	Chr3:93350937-93350949 (+)	1,306 bp
Tssr30354	Chr3:93350955-93350964 (+)	1,323 bp
Tssr30355	Chr3:93350974-93350983 (+)	1,342 bp
Tssr30356	Chr3:93350987-93351037 (+)	1,375 bp
Tssr30357	Chr3:93351085-93351092 (+)	1,452 bp
Tssr30358	Chr3:93351200-93351210 (+)	1,568 bp
Tssr30359	Chr3:93351229-93351236 (+)	1,596 bp
Tssr30360	Chr3:93351259-93351266 (+)	1,626 bp
Tssr961	Chr3:93351310-93351313 (+)	1,675 bp
Tssr30361	Chr3:93351584-93351591 (+)	1,951 bp
Tssr30362	Chr3:93351598-93351607 (+)	1,966 bp
Tssr30363	Chr3:93351741-93351749 (+)	2,108 bp
Tssr30364	Chr3:93351812-93351821 (+)	2,180 bp
Tssr30365	Chr3:93351847-93351856 (+)	2,215 bp
Tssr30366	Chr3:93351899-93351909 (+)	2,267 bp
Tssr30367	Chr3:93351943-93351948 (+)	2,309 bp
Tssr30368	Chr3:93351960-93351972 (+)	2,329 bp
Tssr30369	Chr3:93351973-93351976 (+)	2,338 bp
Tssr30370	Chr3:93351980-93351985 (+)	2,346 bp
Tssr30371	Chr3:93352000-93352012 (+)	2,369 bp
Tssr30372	Chr3:93352013-93352022 (+)	2,381 bp
Tssr30373	Chr3:93352064-93352075 (+)	2,433 bp
Tssr30374	Chr3:93352082-93352089 (+)	2,449 bp
Tssr30375	Chr3:93352095-93352102 (+)	2,462 bp
Tssr30376	Chr3:93352121-93352138 (+)	2,493 bp
Tssr30377	Chr3:93352143-93352164 (+)	2,517 bp
Tssr30378	Chr3:93352176-93352186 (+)	2,544 bp
Tssr30379	Chr3:93352194-93352203 (+)	2,562 bp
Tssr30380	Chr3:93352274-93352282 (+)	2,641 bp
Tssr30381	Chr3:93352292-93352299 (+)	2,659 bp
Tssr30382	Chr3:93352351-93352354 (+)	2,716 bp
Tssr30383	Chr3:93352362-93352365 (+)	2,727 bp
Tssr30384	Chr3:93352371-93352374 (+)	2,736 bp
Tssr30385	Chr3:93352387-93352399 (+)	2,756 bp
Tssr30386	Chr3:93352408-93352421 (+)	2,778 bp
Tssr962	Chr3:93352430-93352433 (+)	2,795 bp
Tssr963	Chr3:93352467-93352469 (+)	2,831 bp
Tssr30387	Chr3:93352499-93352515 (+)	2,870 bp
Tssr30388	Chr3:93352525-93352534 (+)	2,893 bp
Tssr30389	Chr3:93352539-93352556 (+)	2,911 bp
Tssr964	Chr3:93352563-93352568 (+)	2,929 bp
Tssr30390	Chr3:93352611-93352627 (+)	2,982 bp
Tssr30391	Chr3:93352630-93352637 (+)	2,997 bp
Tssr30392	Chr3:93352648-93352655 (+)	3,015 bp
Tssr30393	Chr3:93352665-93352666 (+)	3,029 bp
Tssr30394	Chr3:93352685-93352692 (+)	3,052 bp
Tssr30395	Chr3:93352710-93352719 (+)	3,078 bp
Tssr30396	Chr3:93352759-93352769 (+)	3,127 bp
Tssr30397	Chr3:93352776-93352785 (+)	3,144 bp
Tssr30398	Chr3:93352851-93352863 (+)	3,220 bp
Tssr30399	Chr3:93352898-93352942 (+)	3,283 bp
Tssr30400	Chr3:93353383-93353391 (+)	3,750 bp
Tssr30401	Chr3:93353403-93353412 (+)	3,771 bp
Tssr30402	Chr3:93353502-93353512 (+)	3,870 bp
Tssr30403	Chr3:93353542-93353549 (+)	3,909 bp
Tssr30404	Chr3:93354680-93354688 (+)	5,047 bp
Tssr30405	Chr3:93354791-93354803 (+)	5,160 bp
Tssr30406	Chr3:93354939-93354950 (+)	5,308 bp
Tssr30407	Chr3:93355134-93355140 (+)	5,500 bp