About   Help   FAQ
Akap9 Gene Detail
Summary
  • Symbol
    Akap9
  • Name
    A kinase anchor protein 9
  • Synonyms
    5730481H23Rik, AKAP450, G1-448-15, mei2-5, mKIAA0803, repro12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178217
    NCBI Gene: 100986
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:3977410-4130204 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.26 cM, cytoband A2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178217
 protein coding gene Chr5:3977410-4131310 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029266
 protein coding gene Chr5:757060-906447 (+)
A/J MGP_AJ_G0029230
 protein coding gene Chr5:644445-798898 (+)
AKR/J MGP_AKRJ_G0029180
 protein coding gene Chr5:647814-802634 (+)
BALB/cJ MGP_BALBcJ_G0029248
 protein coding gene Chr5:860925-1007993 (+)
C3H/HeJ MGP_C3HHeJ_G0028968
 protein coding gene Chr5:842969-1006374 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029697
 protein coding gene Chr5:1029448-1190025 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026939
 protein coding gene Chr5:661980-805883 (+)
CAST/EiJ MGP_CASTEiJ_G0028381
 protein coding gene Chr5:847448-1012735 (+)
CBA/J MGP_CBAJ_G0028929
 protein coding gene Chr5:952183-1095648 (+)
DBA/2J MGP_DBA2J_G0029081
 protein coding gene Chr5:809581-959005 (+)
FVB/NJ MGP_FVBNJ_G0029042
 protein coding gene Chr5:701063-844639 (+)
LP/J MGP_LPJ_G0029171
 protein coding gene Chr5:820541-979662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029069
 protein coding gene Chr5:828106-1000923 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029729
 protein coding gene Chr5:770140-923964 (+)
PWK/PhJ MGP_PWKPhJ_G0028100
 protein coding gene Chr5:767747-914262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027934
 protein coding gene Chr5:1069177-1220569 (+)
WSB/EiJ MGP_WSBEiJ_G0028461
 protein coding gene Chr5:790933-940176 (+)



Homology
more
  • Human Ortholog
    AKAP9, A-kinase anchoring protein 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP9, A-kinase anchoring protein 9
  • Synonyms
    AKAP350, AKAP450, AKAP-9, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO
  • Links
    NCBI Gene ID: 10142
    neXtProt AC: NX_Q99996
    UniProt: Q99996

  • Chr Location
    7q21.2; chr7:91940840-92110673 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AKAP9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 4 alleles in 9 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a chemically induced allele exhibit male infertily with abnormal spermatogenesis and Sertoli maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    41
  • cDNA Data
    16
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100986 NCBI Gene Model | MGI Sequence Detail 152795 C57BL/6J ±  kb
    transcript NM_194462 RefSeq | MGI Sequence Detail 12105 Not Specified  
    polypeptide Q70FJ1 UniProt | EBI | MGI Sequence Detail 3797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000003896 A-kinase anchor protein 9
      (term hierarchy)
    • InterPro Domains
      IPR028745 A-kinase anchor protein 9/Pericentrin
      IPR019528 Pericentrin/AKAP-450 centrosomal targeting domain
    • GlyGen
      Q70FJ1 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1913889, MGI:2141218, MGI:2141306, MGI:3050556, MGI:3512794
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory