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Zfp366 Gene Detail
Summary
  • Symbol
    Zfp366
  • Name
    zinc finger protein 366
  • Synonyms
    DC-SCRIPT
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178429
    NCBI Gene: 238803
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:99321331-99383540 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1898 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178429
 protein coding gene Chr13:99321331-99387164 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020873
 protein coding gene Chr13:100964480-101026818 (+)
A/J MGP_AJ_G0020827
 protein coding gene Chr13:97089404-97153510 (+)
AKR/J MGP_AKRJ_G0020801
 protein coding gene Chr13:100064033-100125849 (+)
BALB/cJ MGP_BALBcJ_G0020825
 protein coding gene Chr13:97793458-97857191 (+)
C3H/HeJ MGP_C3HHeJ_G0020616
 protein coding gene Chr13:99798442-99861070 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021259
 protein coding gene Chr13:103959713-104026847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018828
 protein coding gene Chr13:92822829-92886516 (+)
CAST/EiJ MGP_CASTEiJ_G0020134
 protein coding gene Chr13:99155392-99258942 (+)
CBA/J MGP_CBAJ_G0020576
 protein coding gene Chr13:108110169-108173633 (+)
DBA/2J MGP_DBA2J_G0020701
 protein coding gene Chr13:96854571-96922598 (+)
FVB/NJ MGP_FVBNJ_G0020682
 protein coding gene Chr13:95603180-95666239 (+)
LP/J MGP_LPJ_G0020776
 protein coding gene Chr13:101064762-101129915 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020710
 protein coding gene Chr13:108409550-108473634 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021300
 protein coding gene Chr13:99508009-99573659 (+)
PWK/PhJ MGP_PWKPhJ_G0019887
 protein coding gene Chr13:95674676-95737948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019710
 protein coding gene Chr13:95804907-95866768 (+)
WSB/EiJ MGP_WSBEiJ_G0020192
 protein coding gene Chr13:99946928-100012021 (+)



Homology
more
  • Human Ortholog
    ZNF366, zinc finger protein 366
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF366, zinc finger protein 366
  • Synonyms
    DC-SCRIPT, DCSCRIPT
  • Links
    NCBI Gene ID: 167465
    neXtProt AC: NX_Q8N895
    UniProt: Q8N895

  • Chr Location
    5q13.2
Human Diseases
more
  • Diseases
    1 with Zfp366 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    17 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit perimembranous and muscular ventricular septal defects (VSD), and overriding aorta. Short snout, micrognathia, micropthalmia, hypoplastic thymus, and hydronephrosis are also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 238803 NCBI Gene Model | MGI Sequence Detail 62210 C57BL/6J ±  kb
    transcript NM_001004149 RefSeq | MGI Sequence Detail 2788 C57BL/6  
    polypeptide Q6NS86 UniProt | EBI | MGI Sequence Detail 746 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 27
      Diseases 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:108659 Triantis V, et al., Molecular characterization of the murine homologue of the DC-derived protein DC-SCRIPT. J Leukoc Biol. 2006 May;79(5):1083-91
    • Latest
      J:345531 Zhang S, et al., Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT. Sci Immunol. 2021 Apr 2;6(58):eabf4432
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory