Nt5c2 MGI Mouse Gene Detail - MGI:2178563 - 5'-nucleotidase, cytosolic II

Symbol

Nt5c2
Name

5'-nucleotidase, cytosolic II
Synonyms

cN-II, NT5B, PNT5

Feature Type

protein coding gene
IDs

MGI:2178563
NCBI Gene: 76952
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr19:46873829-47003613 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.97 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

3383 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2178563	protein coding gene	Chr19:46871756-47003613 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025218	protein coding gene	Chr19:46649644-46784730 (-)
A/J	MGP_AJ_G0025194	protein coding gene	Chr19:44316850-44446577 (-)
AKR/J	MGP_AKRJ_G0025163	protein coding gene	Chr19:45761449-45903985 (-)
BALB/cJ	MGP_BALBcJ_G0025189	protein coding gene	Chr19:44368655-44497740 (-)
C3H/HeJ	MGP_C3HHeJ_G0024949	protein coding gene	Chr19:45947704-46084897 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025632	protein coding gene	Chr19:47774057-47910436 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023046	protein coding gene	Chr19:43550377-43692179 (-)
CAST/EiJ	MGP_CASTEiJ_G0024414	protein coding gene	Chr19:45761516-45896820 (-)
CBA/J	MGP_CBAJ_G0024929	protein coding gene	Chr19:50190241-50334832 (-)
DBA/2J	MGP_DBA2J_G0025061	protein coding gene	Chr19:44130011-44259323 (-)
FVB/NJ	MGP_FVBNJ_G0025022	protein coding gene	Chr19:43924820-44053827 (-)
LP/J	MGP_LPJ_G0025147	protein coding gene	Chr19:46543024-46680365 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025053	protein coding gene	Chr19:49495324-49630294 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025690	protein coding gene	Chr19:45880393-46019418 (-)
PWK/PhJ	MGP_PWKPhJ_G0024163	protein coding gene	Chr19:44091422-44225571 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023967	protein coding gene	Chr19:44534619-44669951 (-)
WSB/EiJ	MGP_WSBEiJ_G0024484	protein coding gene	Chr19:46033954-46167241 (-)

Human Ortholog

NT5C2, 5'-nucleotidase, cytosolic II

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NT5C2, 5'-nucleotidase, cytosolic II
Synonyms

cN-II, GMP, NT5B, PNT5, SPG45, SPG65
Links

HGNC:8022

NCBI Gene ID: 22978

neXtProt AC: NX_P49902

UniProt: P49902
Chr Location

10q24.32-q24.33; chr10:103087185-103277605 (-) GRCh38

MGI Vertebrate Homology

Nt5c2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NT5C2
Protein SuperFamily

Purine_5'-nucleotidase
Gene Tree

Nt5c2

Diseases

1 with human NT5C2 associations

				Human Disease	Mouse Models
				hereditary spastic paraplegia 45 IDs hereditary spastic paraplegia 45 DOID:0110797 ICD10CM:G11.4 OMIM:613162 ORDO:320396

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

73
Endonuclease-mediated

3
Gene trapped

64
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Bone marrow cells with a nucleotide substitution allele used in a transplantation experiment following tamoxifen-induction produce NOTCH1-induced tumors that are resistant to 6-mercaptopurine chemotherapy.

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All GO Annotations

44
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

827
Tissues

96
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nt5c2

ZFIN nt5c2a, nt5c2b

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All Sequences

143
RefSeq

55
UniProt

10
CCDS

CCDS29883.1, CCDS50461.1, CCDS50462.1

Ensembl

ENSMUSG00000025041 (Evidence)
NCBI Gene

76952

			Length	Strain/Species	Flank
genomic	76952	NCBI Gene Model \| MGI Sequence Detail	129785	C57BL/6J	± kb
transcript	NR_165074	RefSeq \| MGI Sequence Detail	5860	C57BL/6
polypeptide	Q3V1L4	UniProt \| EBI \| MGI Sequence Detail	560	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011454 cytosolic purine 5'-nucleotidase

(term hierarchy)
EC

2.7.1.77, 3.1.3.5, 3.1.3.99
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR008380 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase

IPR016695 Purine 5'-nucleotidase

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All nucleic 17

cDNA 16

Other 1

Microarray probesets 5

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MGI:1924202

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 12
Earliest

J:297459 Magnusson G, Deoxyribonucleotide phosphatase from rat liver and cultured mouse fibroblasts. Eur J Biochem. 1971 May 28;20(2):225-30
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nt5c2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159690	Chr19:47003552-47003645 (-)	14 bp
Tssr159689	Chr19:46976248-46976259 (-)	27,359 bp
Tssr159688	Chr19:46973811-46973837 (-)	29,789 bp
Tssr159687	Chr19:46973802-46973807 (-)	29,808 bp
Tssr159686	Chr19:46958001-46958011 (-)	45,607 bp
Tssr159685	Chr19:46957979-46957994 (-)	45,626 bp
Tssr159684	Chr19:46950948-46951018 (-)	52,630 bp
Tssr159683	Chr19:46950764-46950772 (-)	52,845 bp
Tssr159682	Chr19:46950740-46950756 (-)	52,865 bp
Tssr159681	Chr19:46950375-46950411 (-)	53,220 bp
Tssr159680	Chr19:46950355-46950369 (-)	53,251 bp
Tssr159679	Chr19:46950315-46950334 (-)	53,288 bp
Tssr159678	Chr19:46935081-46935100 (-)	68,522 bp
Tssr159677	Chr19:46932377-46932394 (-)	71,227 bp
Tssr159676	Chr19:46929474-46929483 (-)	74,134 bp
Tssr159675	Chr19:46920737-46920741 (-)	82,874 bp
Tssr159674	Chr19:46917661-46917666 (-)	85,949 bp
Tssr159673	Chr19:46913997-46914001 (-)	89,614 bp
Tssr159672	Chr19:46897084-46897088 (-)	106,527 bp
Tssr159671	Chr19:46889906-46889910 (-)	113,705 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24