About   Help   FAQ
Defb11 Gene Detail
Summary
  • Symbol
    Defb11
  • Name
    defensin beta 11
  • Synonyms
    Defb8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179197
    NCBI Gene: 246081
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22395392-22396428 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.59 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179197
 protein coding gene Chr8:22395383-22396448 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033436
 protein coding gene Chr8:19730903-19731882 (-)
A/J MGP_AJ_G0033416
 protein coding gene Chr8:19092397-19093376 (-)
AKR/J MGP_AKRJ_G0033341
 protein coding gene Chr8:19719243-19720033 (-)
BALB/cJ MGP_BALBcJ_G0033412
 protein coding gene Chr8:19215148-19216127 (-)
C3H/HeJ MGP_C3HHeJ_G0033126
 protein coding gene Chr8:19914248-19915227 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033929
 protein coding gene Chr8:20571550-20573556 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032452
 protein coding gene Chr8:19337576-19338524 (-)
CBA/J MGP_CBAJ_G0033101
 protein coding gene Chr8:21391297-21392276 (-)
DBA/2J MGP_DBA2J_G0033256
 protein coding gene Chr8:19061010-19061989 (-)
FVB/NJ MGP_FVBNJ_G0033200
 protein coding gene Chr8:18867269-18868248 (-)
LP/J MGP_LPJ_G0033345
 protein coding gene Chr8:19720525-19721505 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033243
 protein coding gene Chr8:21004062-21005041 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033948
 protein coding gene Chr8:19624096-19625132 (-)
PWK/PhJ MGP_PWKPhJ_G0032164
 protein coding gene Chr8:18660258-18661244 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031997
 protein coding gene Chr8:18998415-18999409 (-)
WSB/EiJ MGP_WSBEiJ_G0032569
 protein coding gene Chr8:19796304-19805234 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    27
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045337 Ensembl Gene Model | MGI Sequence Detail 1037 C57BL/6J ±  kb
transcript ENSMUST00000051965 Ensembl | MGI Sequence Detail 317 Not Applicable  
polypeptide ENSMUSP00000053932 Ensembl | MGI Sequence Detail 77 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:75063 Schutte BC, et al., Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory