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Klhl8 Gene Detail
Summary
  • Symbol
    Klhl8
  • Name
    kelch-like 8
  • Synonyms
    2310001P09Rik, D5Ertd431e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179430
    NCBI Gene: 246293
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:104009916-104059137 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.45 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1611 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179430
 protein coding gene Chr5:104009839-104059137 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029804
 protein coding gene Chr5:105518231-105567875 (-)
A/J MGP_AJ_G0029768
 protein coding gene Chr5:101550622-101599101 (-)
AKR/J MGP_AKRJ_G0029716
 protein coding gene Chr5:104821805-104856181 (-)
BALB/cJ MGP_BALBcJ_G0029780
 protein coding gene Chr5:102614413-102662968 (-)
C3H/HeJ MGP_C3HHeJ_G0029503
 protein coding gene Chr5:105238240-105287795 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030235
 protein coding gene Chr5:109819779-109870323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027470
 protein coding gene Chr5:96691905-96742162 (-)
CAST/EiJ MGP_CASTEiJ_G0028914
 protein coding gene Chr5:103944117-103994529 (-)
CBA/J MGP_CBAJ_G0029473
 protein coding gene Chr5:113651559-113706097 (-)
DBA/2J MGP_DBA2J_G0029617
 protein coding gene Chr5:101742611-101790590 (-)
FVB/NJ MGP_FVBNJ_G0029576
 protein coding gene Chr5:100543158-100592709 (-)
LP/J MGP_LPJ_G0029705
 protein coding gene Chr5:106088382-106137515 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029605
 protein coding gene Chr5:118596664-118647549 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030268
 protein coding gene Chr5:104363855-104414717 (-)
PWK/PhJ MGP_PWKPhJ_G0028632
 protein coding gene Chr5:100198742-100247210 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028467
 protein coding gene Chr5:102021540-102073863 (-)
WSB/EiJ MGP_WSBEiJ_G0028992
 protein coding gene Chr5:104735625-104787299 (-)



Homology
more
  • Human Ortholog
    KLHL8, kelch like family member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHL8, kelch like family member 8
  • Links
    NCBI Gene ID: 57563
    neXtProt AC: NX_Q9P2G9
    UniProt: Q9P2G9

  • Chr Location
    4q22.1; chr4:87160103-87240531 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotype references
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    18
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Klhl8
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    41 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    25
  • cDNA Data
    13
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246293 NCBI Gene Model | MGI Sequence Detail 49222 C57BL/6J ±  kb
transcript NM_001359986 RefSeq | MGI Sequence Detail 3260 ZRU/MplStud  
polypeptide P59280 UniProt | EBI | MGI Sequence Detail 629 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1196339, MGI:1915108
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory