Mpst MGI Mouse Gene Detail - MGI:2179733 - mercaptopyruvate sulfurtransferase

Symbol

Mpst
Name

mercaptopyruvate sulfurtransferase
Synonyms

3MST

Feature Type

protein coding gene
IDs

MGI:2179733
NCBI Gene: 246221
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:78290918-78298213 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.47 cM, cytoband E2
Mapping Data

1 experiment

SNPs within 2kb

265 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2179733	protein coding gene	Chr15:78290616-78298213 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022042	protein coding gene	Chr15:78600681-78607972 (+)
A/J	MGP_AJ_G0022003	protein coding gene	Chr15:75905058-75912349 (+)
AKR/J	MGP_AKRJ_G0021978	protein coding gene	Chr15:77993663-78000952 (+)
BALB/cJ	MGP_BALBcJ_G0022009	protein coding gene	Chr15:75878417-75885708 (+)
C3H/HeJ	MGP_C3HHeJ_G0021780	protein coding gene	Chr15:78011280-78018569 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022452	protein coding gene	Chr15:81703712-81711001 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019982	protein coding gene	Chr15:72403025-72410544 (+)
CAST/EiJ	MGP_CASTEiJ_G0021301	protein coding gene	Chr15:78688442-78695867 (+)
CBA/J	MGP_CBAJ_G0021745	protein coding gene	Chr15:84224098-84231388 (+)
DBA/2J	MGP_DBA2J_G0021874	protein coding gene	Chr15:75388390-75395683 (+)
FVB/NJ	MGP_FVBNJ_G0021852	protein coding gene	Chr15:74388953-74396244 (+)
LP/J	MGP_LPJ_G0021942	protein coding gene	Chr15:78806419-78813536 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021872	protein coding gene	Chr15:89419113-89426405 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022466	protein coding gene	Chr15:78036321-78043613 (+)
PWK/PhJ	MGP_PWKPhJ_G0021043	protein coding gene	Chr15:75386927-75394300 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020880	protein coding gene	Chr15:77808480-77817484 (+)
WSB/EiJ	MGP_WSBEiJ_G0021353	protein coding gene	Chr15:78388883-78396176 (+)

Human Ortholog

MPST, mercaptopyruvate sulfurtransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPST, mercaptopyruvate sulfurtransferase
Synonyms

MST, TST2, TUM1
Links

HGNC:7223

NCBI Gene ID: 4357

neXtProt AC: NX_P25325

UniProt: P25325
Chr Location

22q12.3; chr22:37019635-37029821 (+) GRCh38

MGI Vertebrate Homology

Mpst stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MPST
Gene Tree

Mpst

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 3 alleles in 2 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

5
Radiation induced

2
Targeted

5
Transgenic

2
Genomic Mutations

3 involving Mpst
Incidental Mutations

CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a knock-out allele exhibit reduced male fertility. Mice homozygous for a knock-out allele exhibit normal fertility but increased anxiety-related behaviors and increased serotonin metabolite levels in the brain.

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All GO Annotations

24
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

27

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mpst

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All Sequences

57
RefSeq

16
UniProt

3
CCDS

CCDS27615.1

Ensembl

ENSMUSG00000071711 (Evidence)
NCBI Gene

246221

			Length	Strain/Species	Flank
genomic	246221	NCBI Gene Model \| MGI Sequence Detail	7296	C57BL/6J	± kb
transcript	NM_138670	RefSeq \| MGI Sequence Detail	1810	C57BL/6
polypeptide	Q99J99	UniProt \| EBI \| MGI Sequence Detail	297	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010550 3-mercaptopyruvate sulfurtransferase

(term hierarchy)
PDB

5WQJ, 5WQK
EC

2.8.1.2
InterPro Domains

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR045078 Sulfurtransferase TST/MPST-like

IPR001307 Thiosulphate sulfurtransferase, conserved site
GlyGen

Q99J99 1 site, 1 O-linked glycan (1 site)

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All nucleic 28

cDNA 27

Primer pair 1

Microarray probesets 3

Summaries

All 65

Diseases 1

Gene Ontology 11

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345900 Drekolia MK, et al., Loss of cardiac mitochondrial complex I persulfidation impairs NAD(+) homeostasis in aging. Redox Biol. 2024 Feb;69:103014

TSS for Mpst:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131943	Chr15:78290383-78290387 (+)	-533 bp
Tssr131944	Chr15:78290895-78290932 (+)	-4 bp
Tssr131945	Chr15:78290977-78290996 (+)	69 bp
Tssr131946	Chr15:78293913-78293928 (+)	3,003 bp
Tssr131947	Chr15:78293939-78293948 (+)	3,026 bp
Tssr131948	Chr15:78293960-78293976 (+)	3,050 bp
Tssr131949	Chr15:78294110-78294122 (+)	3,198 bp
Tssr131950	Chr15:78294154-78294238 (+)	3,278 bp
Tssr131951	Chr15:78294479-78294484 (+)	3,564 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24