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Xpnpep2 Gene Detail
Summary
  • Symbol
    Xpnpep2
  • Name
    X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
  • Synonyms
    9030008G12Rik, mAPP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180001
    NCBI Gene: 170745
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:47197602-47225858 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 25.52 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180001
 protein coding gene ChrX:47195790-47225859 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035687
 protein coding gene ChrX:43241875-43270045 (+)
A/J MGP_AJ_G0035670
 protein coding gene ChrX:43113986-43143478 (+)
AKR/J MGP_AKRJ_G0035590
 protein coding gene ChrX:44294625-44323813 (+)
BALB/cJ MGP_BALBcJ_G0035656
 protein coding gene ChrX:42767321-42795531 (+)
C3H/HeJ MGP_C3HHeJ_G0035360
 protein coding gene ChrX:43543652-43571888 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036185
 protein coding gene ChrX:44273193-44301448 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033037
 protein coding gene ChrX:40807265-40835151 (+)
CAST/EiJ MGP_CASTEiJ_G0034651
 protein coding gene ChrX:31124670-31154801 (+)
CBA/J MGP_CBAJ_G0035334
 protein coding gene ChrX:45509155-45538505 (+)
DBA/2J MGP_DBA2J_G0035488
 protein coding gene ChrX:42966127-42994610 (+)
FVB/NJ MGP_FVBNJ_G0035437
 protein coding gene ChrX:42672904-42701659 (+)
LP/J MGP_LPJ_G0035576
 protein coding gene ChrX:43607353-43635795 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035475
 protein coding gene ChrX:46922984-46952710 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036203
 protein coding gene ChrX:43153997-43184288 (+)
PWK/PhJ MGP_PWKPhJ_G0034350
 protein coding gene ChrX:30609677-30638326 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034195
 protein coding gene ChrX:31908900-31938935 (+)
WSB/EiJ MGP_WSBEiJ_G0034795
 protein coding gene ChrX:42778807-42807046 (+)



Homology
more
  • Human Ortholog
    XPNPEP2, X-prolyl aminopeptidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XPNPEP2, X-prolyl aminopeptidase 2
  • Synonyms
    AEACEI, APP2
  • Links
    NCBI Gene ID: 7512
    neXtProt AC: NX_O43895
    UniProt: O43895

  • Chr Location
    Xq26.1; chrX:129738949-129769536 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human XPNPEP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    15
  • cDNA Data
    13
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037005 Ensembl Gene Model | MGI Sequence Detail 28257 C57BL/6J ±  kb
transcript ENSMUST00000115000 Ensembl | MGI Sequence Detail 3184 Not Applicable  
polypeptide ENSMUSP00000110652 Ensembl | MGI Sequence Detail 741 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 2
Other
Accession IDs
less
MGI:2442316
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory