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Edem1 Gene Detail
Summary
  • Symbol
    Edem1
  • Name
    ER degradation enhancer, mannosidase alpha-like 1
  • Synonyms
    A130059K23Rik, mKIAA0212
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180139
    NCBI Gene: 192193
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:108805602-108836317 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 49.87 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    829 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180139
 protein coding gene Chr6:108800984-108836317 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031103
 protein coding gene Chr6:111117088-111163352 (+)
A/J MGP_AJ_G0031072
 protein coding gene Chr6:106912001-106942987 (+)
AKR/J MGP_AKRJ_G0031003
 protein coding gene Chr6:109791307-109825601 (+)
BALB/cJ MGP_BALBcJ_G0031083
 protein coding gene Chr6:106836409-106867957 (+)
C3H/HeJ MGP_C3HHeJ_G0030625
 protein coding gene Chr6:74533541-74567059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031542
 protein coding gene Chr6:114036682-114068830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028706
 protein coding gene Chr6:104195099-104225409 (+)
CAST/EiJ MGP_CASTEiJ_G0030190
 protein coding gene Chr6:110176358-110208447 (+)
CBA/J MGP_CBAJ_G0030769
 protein coding gene Chr6:118435487-118475864 (+)
DBA/2J MGP_DBA2J_G0030922
 protein coding gene Chr6:106045175-106078194 (+)
FVB/NJ MGP_FVBNJ_G0030876
 protein coding gene Chr6:105077027-105112872 (+)
LP/J MGP_LPJ_G0031002
 protein coding gene Chr6:111174633-111210028 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030910
 protein coding gene Chr6:122637489-122678141 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031569
 protein coding gene Chr6:109738426-109770100 (+)
PWK/PhJ MGP_PWKPhJ_G0029906
 protein coding gene Chr6:104981687-105013491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029734
 protein coding gene Chr6:108522037-108553741 (+)
WSB/EiJ MGP_WSBEiJ_G0030274
 protein coding gene Chr6:110267669-110302397 (+)



Homology
more
  • Human Ortholog
    EDEM1, ER degradation enhancing alpha-mannosidase like protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EDEM1, ER degradation enhancing alpha-mannosidase like protein 1
  • Synonyms
    EDEM
  • Links
    NCBI Gene ID: 9695
    neXtProt AC: NX_Q92611
    UniProt: Q92611

  • Chr Location
    3p26.1; chr3:5187646-5219958 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    3
  • cDNA Data
    183
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030104 Ensembl Gene Model | MGI Sequence Detail 30716 C57BL/6J ±  kb
    transcript ENSMUST00000089162 Ensembl | MGI Sequence Detail 5817 Not Applicable  
    polypeptide ENSMUSP00000086565 Ensembl | MGI Sequence Detail 652 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006892 ER degradation-enhancing alpha-mannosidase-like protein 1
      (term hierarchy)
    • EC
      3.2.1.-
    • InterPro Domains
      IPR044674 ER degradation-enhancing alpha-mannosidase-like protein 1/2/3
      IPR001382 Glycoside hydrolase family 47
      IPR036026 Seven-hairpin glycosidases
      IPR012341 Six-hairpin glycosidase-like superfamily
    • GlyGen
      Q925U4 4 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 186
      cDNA 183
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442942
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 14
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:76183 Hosokawa N, et al., A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep. 2001 May;2(5):415-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory