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Oas2 Gene Detail
Summary
  • Symbol
    Oas2
  • Name
    2'-5' oligoadenylate synthetase 2
  • Synonyms
    2'-5' oligoadenylate synthetase-like 11, Oasl11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180852
    NCBI Gene: 246728
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120868398-120887918 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    629 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180852
 protein coding gene Chr5:120868398-120887949 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030013
 protein coding gene Chr5:124137409-124156732 (-)
A/J MGP_AJ_G0029977
 protein coding gene Chr5:118979305-118998610 (-)
AKR/J MGP_AKRJ_G0029916
 protein coding gene Chr5:122820914-122840225 (-)
BALB/cJ MGP_BALBcJ_G0029988
 protein coding gene Chr5:120395743-120415292 (-)
C3H/HeJ MGP_C3HHeJ_G0029708
 protein coding gene Chr5:123360092-123380431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030443
 protein coding gene Chr5:128785906-128806057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027669
 protein coding gene Chr5:113684198-113703396 (-)
CAST/EiJ MGP_CASTEiJ_G0029117
 protein coding gene Chr5:122488458-122509454 (-)
CBA/J MGP_CBAJ_G0029676
 protein coding gene Chr5:133795430-133814784 (-)
DBA/2J MGP_DBA2J_G0029826
 protein coding gene Chr5:119064410-119086905 (-)
FVB/NJ MGP_FVBNJ_G0029782
 protein coding gene Chr5:117997949-118017926 (-)
LP/J MGP_LPJ_G0029914
 protein coding gene Chr5:124582691-124602031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029813
 protein coding gene Chr5:137739214-137758491 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030484
 protein coding gene Chr5:122398320-122417660 (-)
PWK/PhJ MGP_PWKPhJ_G0028830
 protein coding gene Chr5:117826962-117847584 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028669
 protein coding gene Chr5:120065460-120084683 (-)
WSB/EiJ MGP_WSBEiJ_G0029192
 protein coding gene Chr5:122990712-123012382 (-)



Homology
more
  • Human Ortholog
    OAS2, 2'-5'-oligoadenylate synthetase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS2, 2'-5'-oligoadenylate synthetase 2
  • Links
    NCBI Gene ID: 4939
    neXtProt AC: NX_P29728
    UniProt: P29728

  • Chr Location
    12q24.13; chr12:112978395-113011723 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In nursing mothers, homozygous knockout (by a point mutation in a critical domain) results in a failure of the alveoli to expand and a failure to lactate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    1
  • cDNA Data
    26
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032690 Ensembl Gene Model | MGI Sequence Detail 19521 C57BL/6J ±  kb
    transcript ENSMUST00000081491 Ensembl | MGI Sequence Detail 3961 Not Applicable  
    polypeptide ENSMUSP00000080209 Ensembl | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011575 2'-5'-oligoadenylate synthase 2
      (term hierarchy)
    • EC
      2.7.7.84
    • InterPro Domains
      IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
      IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
      IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site
      IPR043518 2-5-oligoadenylate synthetase, N-terminal conserved site
      IPR043519 Nucleotidyltransferase superfamily
      IPR002934 Polymerase, nucleotidyl transferase domain
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 7
      cDNA 26
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:288075 Kwock JT, et al., IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection. Sci Adv. 2020 Apr;6(14):eaay3245
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory