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Oas1e Gene Detail
Summary
  • Symbol
    Oas1e
  • Name
    2'-5' oligoadenylate synthetase 1E
  • Synonyms
    2'-5' oligoadenylate synthetase-like 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180856
    NCBI Gene: 231699
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:120924377-120933595 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180856
 protein coding gene Chr5:120924291-120933595 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030017
 protein coding gene Chr5:124272606-124353824 (+)
A/J MGP_AJ_G0029979
 protein coding gene Chr5:119035849-119045473 (-)
AKR/J MGP_AKRJ_G0029921
 protein coding gene Chr5:122975461-123034699 (+)
BALB/cJ MGP_BALBcJ_G0029990
 protein coding gene Chr5:120451585-120460989 (-)
C3H/HeJ MGP_C3HHeJ_G0029710
 protein coding gene Chr5:123447277-123460351 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030445
 protein coding gene Chr5:128858396-128866118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027675
 protein coding gene Chr5:113867945-113890421 (+)
CAST/EiJ MGP_CASTEiJ_G0029122
 protein coding gene Chr5:122715161-122728886 (+)
CBA/J MGP_CBAJ_G0029678
 protein coding gene Chr5:133888478-133897768 (-)
DBA/2J MGP_DBA2J_G0029828
 protein coding gene Chr5:119119405-119130046 (-)
FVB/NJ MGP_FVBNJ_G0029786
 protein coding gene Chr5:118149259-118248721 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0030486
 protein coding gene Chr5:122456287-122469440 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0029197
 protein coding gene Chr5:123152503-123163924 (+)



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Synonyms
    E18/E16, IFI-4, IMD100, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112905856-112933219 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    18
  • cDNA Data
    20
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 231699 NCBI Gene Model | MGI Sequence Detail 9219 C57BL/6J ±  kb
transcript NM_145210 RefSeq | MGI Sequence Detail 1715 ZRU/MplStud  
polypeptide NP_001334379 RefSeq | MGI Sequence Detail 386 ZRU/MplStud  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR043519 Nucleotidyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 26
    Genomic 5
    cDNA 20
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141342
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:307968 He Y, et al., Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. Aging Cell. 2021 Jul;20(7):e13424
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory