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Oas1a Gene Detail
Summary
  • Symbol
    Oas1a
  • Name
    2'-5' oligoadenylate synthetase 1A
  • Synonyms
    L3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180860
    NCBI Gene: 246730
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121034319-121045584 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.65 cM, cytoband F
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    403 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180860
 protein coding gene Chr5:121034319-121045588 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0029983
 protein coding gene Chr5:119142884-119175379 (-)
AKR/J MGP_AKRJ_G0029923
 protein coding gene Chr5:123065271-123080087 (-)
BALB/cJ MGP_BALBcJ_G0029994
 protein coding gene Chr5:120603679-120619030 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0027673
 protein coding gene Chr5:113839997-113846041 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0029682
 protein coding gene Chr5:134020547-134096084 (-)
DBA/2J MGP_DBA2J_G0029833
 protein coding gene Chr5:119287022-119294913 (-)
FVB/NJ MGP_FVBNJ_G0029788
 protein coding gene Chr5:118198729-118209808 (-)
LP/J MGP_LPJ_G0029921
 protein coding gene Chr5:124773265-124807201 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029820
 protein coding gene Chr5:137972868-138011450 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0028836
 protein coding gene Chr5:118031734-118046216 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Synonyms
    E18/E16, IFI-4, IMD100, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112905856-112933219 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    11
  • cDNA Data
    46
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052776 Ensembl Gene Model | MGI Sequence Detail 11266 C57BL/6J ±  kb
transcript ENSMUST00000080322 Ensembl | MGI Sequence Detail 1885 Not Applicable  
polypeptide ENSMUSP00000079198 Ensembl | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    Genomic 1
    cDNA 46

    Microarray probesets 1
References
more
  • Summaries
    All 48
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory