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Pth2r Gene Detail
Summary
  • Symbol
    Pth2r
  • Name
    parathyroid hormone 2 receptor
  • Synonyms
    Pthr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180917
    NCBI Gene: 213527
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:65321215-65428403 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.05 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3009 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180917
 protein coding gene Chr1:65317921-65428784 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016110
 protein coding gene Chr1:65487809-65608781 (+)
A/J MGP_AJ_G0016093
 protein coding gene Chr1:63175346-63282235 (+)
AKR/J MGP_AKRJ_G0016050
 protein coding gene Chr1:64945681-65058333 (+)
BALB/cJ MGP_BALBcJ_G0016048
 protein coding gene Chr1:63275452-63388167 (+)
C3H/HeJ MGP_C3HHeJ_G0015879
 protein coding gene Chr1:65219774-65329086 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016501
 protein coding gene Chr1:68026577-68147627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014222
 protein coding gene Chr1:59222007-59335327 (+)
CAST/EiJ MGP_CASTEiJ_G0015463
 protein coding gene Chr1:64492270-64607508 (+)
CBA/J MGP_CBAJ_G0015852
 protein coding gene Chr1:70209221-70336362 (+)
DBA/2J MGP_DBA2J_G0015953
 protein coding gene Chr1:62581378-62688054 (+)
FVB/NJ MGP_FVBNJ_G0015956
 protein coding gene Chr1:61853134-61962706 (+)
LP/J MGP_LPJ_G0016025
 protein coding gene Chr1:66394319-66516784 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015976
 protein coding gene Chr1:73092088-73213712 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016548
 protein coding gene Chr1:64941914-65053389 (+)
PWK/PhJ MGP_PWKPhJ_G0015249
 protein coding gene Chr1:61978550-62089066 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015029
 protein coding gene Chr1:64421424-64546155 (+)
WSB/EiJ MGP_WSBEiJ_G0015525
 protein coding gene Chr1:64648937-64762061 (+)



Homology
more
  • Human Ortholog
    PTH2R, parathyroid hormone 2 receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTH2R, parathyroid hormone 2 receptor
  • Synonyms
    PTHR2
  • Links
    NCBI Gene ID: 5746
    neXtProt AC: NX_P49190
    UniProt: P49190

  • Chr Location
    2q34; chr2:208359692-208854503 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO reduces core body temperature in pregnant and lactating females and affects locomotor and grooming behavior of lactating females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025946 Ensembl Gene Model | MGI Sequence Detail 107189 C57BL/6J ±  kb
    transcript ENSMUST00000027083 Ensembl | MGI Sequence Detail 2414 Not Applicable  
    polypeptide ENSMUSP00000027083 Ensembl | MGI Sequence Detail 546 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013432 parathyroid hormone 2 receptor
      (term hierarchy)
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      Q91V95 4 sites
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory