Acbd3 MGI Mouse Gene Detail - MGI:2181074 - acyl-Coenzyme A binding domain containing 3

Symbol

Acbd3
Name

acyl-Coenzyme A binding domain containing 3
Synonyms

8430407O11Rik, D1Ertd10e, Gocap1, Pap7

Feature Type

protein coding gene
IDs

MGI:2181074
NCBI Gene: 170760
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:180553608-180581769 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.46 cM, cytoband H4
Mapping Data

5 experiments

SNPs within 2kb

536 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181074	protein coding gene	Chr1:180553608-180581769 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016873	protein coding gene	Chr1:187175712-187204803 (+)
A/J	MGP_AJ_G0016852	protein coding gene	Chr1:179607806-179635493 (+)
AKR/J	MGP_AKRJ_G0016818	protein coding gene	Chr1:184943005-184970913 (+)
BALB/cJ	MGP_BALBcJ_G0016810	protein coding gene	Chr1:180232736-180261043 (+)
C3H/HeJ	MGP_C3HHeJ_G0016635	protein coding gene	Chr1:185716099-185745771 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017273	protein coding gene	Chr1:193194754-193225328 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014981	protein coding gene	Chr1:170589414-170617916 (+)
CAST/EiJ	MGP_CASTEiJ_G0016216	protein coding gene	Chr1:185052779-185087214 (+)
CBA/J	MGP_CBAJ_G0016609	protein coding gene	Chr1:200383054-200414978 (+)
DBA/2J	MGP_DBA2J_G0016715	protein coding gene	Chr1:178443613-178471936 (+)
FVB/NJ	MGP_FVBNJ_G0016711	protein coding gene	Chr1:176538232-176567801 (+)
LP/J	MGP_LPJ_G0016789	protein coding gene	Chr1:188433136-188463580 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016742	protein coding gene	Chr1:207562120-207599392 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017310	protein coding gene	Chr1:184724120-184754885 (+)
PWK/PhJ	MGP_PWKPhJ_G0016004	protein coding gene	Chr1:177556510-177586146 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015780	protein coding gene	Chr1:183657864-183683979 (+)
WSB/EiJ	MGP_WSBEiJ_G0016279	protein coding gene	Chr1:184922902-184950790 (+)

Human Ortholog

ACBD3, acyl-CoA binding domain containing 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACBD3, acyl-CoA binding domain containing 3
Synonyms

GCP60, GOCAP1, GOLPH1, PAP7
Links

HGNC:15453

NCBI Gene ID: 64746

neXtProt AC: NX_Q9H3P7

UniProt: Q9H3P7
Chr Location

1q42.12; chr1:226144679-226186741 (-) GRCh38

MGI Vertebrate Homology

Acbd3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACBD3
Gene Tree

Acbd3

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

8
Targeted

4
Genomic Mutations

2 involving Acbd3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

10
cDNA Data

87
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acbd3

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All Sequences

48
RefSeq

2
UniProt

4
CCDS

CCDS15572.1

Ensembl

ENSMUSG00000026499 (Evidence)
NCBI Gene

170760

			Length	Strain/Species	Flank
genomic	170760	NCBI Gene Model \| MGI Sequence Detail	28162	C57BL/6J	± kb
transcript	NM_133225	RefSeq \| MGI Sequence Detail	3487	ZRU/MplStud
polypeptide	Q8BMP6	UniProt \| EBI \| MGI Sequence Detail	525	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003612 Golgi resident protein GCP60

(term hierarchy)
InterPro Domains

IPR000582 Acyl-CoA-binding protein, ACBP

IPR022408 Acyl-CoA-binding protein, ACBP, conserved site

IPR035984 Acyl-CoA binding protein superfamily

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR009038 GOLD domain

IPR036598 GOLD domain superfamily

IPR052269 Golgi apparatus maintenance and PI4KB interaction protein

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All nucleic 88

cDNA 87

Primer pair 1

Microarray probesets 7

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MGI:1098780, MGI:1918743

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acbd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10483	Chr1:180553570-180553582 (+)	-32 bp
Tssr10484	Chr1:180553584-180553671 (+)	20 bp
Tssr10485	Chr1:180553889-180553916 (+)	295 bp
Tssr10486	Chr1:180554838-180554851 (+)	1,237 bp
Tssr10487	Chr1:180559403-180559409 (+)	5,798 bp
Tssr10488	Chr1:180560731-180560755 (+)	7,135 bp
Tssr10489	Chr1:180576480-180576488 (+)	22,876 bp
Tssr10490	Chr1:180577376-180577388 (+)	23,774 bp
Tssr10491	Chr1:180577472-180577496 (+)	23,876 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24