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Mkrn3 Gene Detail
Summary
  • Symbol
    Mkrn3
  • Name
    makorin, ring finger protein, 3
  • Synonyms
    D7H15S9-1, Zfp127
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181178
    NCBI Gene: 22652
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:62067341-62069887 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.37 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181178
 protein coding gene Chr7:62067341-62069901 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032328
 protein coding gene Chr7:63500785-63503331 (-)
A/J MGP_AJ_G0032307
 protein coding gene Chr7:62298925-62301471 (-)
AKR/J MGP_AKRJ_G0032243
 protein coding gene Chr7:63617028-63619574 (-)
BALB/cJ MGP_BALBcJ_G0032319
 protein coding gene Chr7:61983192-61985750 (-)
C3H/HeJ MGP_C3HHeJ_G0032032
 protein coding gene Chr7:64226392-64228938 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032812
 protein coding gene Chr7:66266184-66268730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029819
 protein coding gene Chr7:65325049-65327602 (-)
CAST/EiJ MGP_CASTEiJ_G0031361
 protein coding gene Chr7:55002934-55005486 (-)
CBA/J MGP_CBAJ_G0031998
 protein coding gene Chr7:68398362-68400908 (-)
DBA/2J MGP_DBA2J_G0032154
 protein coding gene Chr7:61120250-61122802 (-)
FVB/NJ MGP_FVBNJ_G0032108
 protein coding gene Chr7:61165931-61168477 (-)
LP/J MGP_LPJ_G0032234
 protein coding gene Chr7:64702281-64704827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032145
 protein coding gene Chr7:68634651-68637242 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032829
 protein coding gene Chr7:62882645-62885191 (-)
PWK/PhJ MGP_PWKPhJ_G0031081
 protein coding gene Chr7:54096410-54098963 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030922
 protein coding gene Chr7:50007277-50009817 (-)
WSB/EiJ MGP_WSBEiJ_G0031479
 protein coding gene Chr7:63260452-63262998 (-)



Homology
more
  • Human Ortholog
    MKRN3, makorin ring finger protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MKRN3, makorin ring finger protein 3
  • Synonyms
    CPPB2, D15S9, RNF63, ZFP127, ZNF127
  • Links
    NCBI Gene ID: 7681
    neXtProt AC: NX_Q13064
    UniProt: Q13064

  • Chr Location
    15q11.2; chr15:23565674-23630075 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mkrn3 mouse models; 1 with human MKRN3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice inheriting a null paternal allele exhibit precocious puberty, with earlier preputial separation and vaginal opening, earlier first time of estrus, and increased luteinizing hormone and follicle stimulating hormone serum levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    19
  • cDNA Data
    12
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070527 Ensembl Gene Model | MGI Sequence Detail 2547 C57BL/6J ±  kb
    transcript ENSMUST00000094340 Ensembl | MGI Sequence Detail 2547 Not Applicable  
    polypeptide ENSMUSP00000091898 Ensembl | MGI Sequence Detail 544 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 13
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15910, MGD-MRK-7794, MGI:99158
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 15
      Diseases 5
      Gene Ontology 5
      Phenotypes 44
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory