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Pfkfb3 Gene Detail
Summary
  • Symbol
    Pfkfb3
  • Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  • Synonyms
    E330010H22Rik, uPFK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181202
    NCBI Gene: 170768
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:11476241-11558882 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 8.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2394 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181202
 protein coding gene Chr2:11476241-11558888 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025343
 protein coding gene Chr2:8884016-8970918 (-)
A/J MGP_AJ_G0025320
 protein coding gene Chr2:8501065-8586146 (-)
AKR/J MGP_AKRJ_G0025289
 protein coding gene Chr2:8803641-8892457 (-)
BALB/cJ MGP_BALBcJ_G0025316
 protein coding gene Chr2:8478833-8563224 (-)
C3H/HeJ MGP_C3HHeJ_G0025076
 protein coding gene Chr2:8723577-8809424 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025758
 protein coding gene Chr2:9119227-9210529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023172
 protein coding gene Chr2:7944297-8026165 (-)
CAST/EiJ MGP_CASTEiJ_G0024539
 protein coding gene Chr2:8757376-8842978 (-)
CBA/J MGP_CBAJ_G0025055
 protein coding gene Chr2:9497359-9585281 (-)
DBA/2J MGP_DBA2J_G0025187
 protein coding gene Chr2:8421630-8505433 (-)
FVB/NJ MGP_FVBNJ_G0025149
 protein coding gene Chr2:8342687-8429529 (-)
LP/J MGP_LPJ_G0025273
 protein coding gene Chr2:8790026-8883734 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025181
 protein coding gene Chr2:9397960-9484805 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025816
 protein coding gene Chr2:8730601-8815106 (-)
PWK/PhJ MGP_PWKPhJ_G0024290
 protein coding gene Chr2:8395537-8479844 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024090
 protein coding gene Chr2:8721932-8808631 (-)
WSB/EiJ MGP_WSBEiJ_G0024609
 protein coding gene Chr2:8801305-8885259 (-)



Homology
more
  • Human Ortholog
    PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  • Synonyms
    iPFK-2, IPFK2, PFK2
  • Links
    NCBI Gene ID: 5209
    neXtProt AC: NX_Q16875
    UniProt: Q16875

  • Chr Location
    10p15.1; chr10:6144921-6326637 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pfkfb3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before E8. Inducible endothelial cell-specific homozygous knockout affects glycolysis in muscle ECs, reducing their proliferation rate and their macrophage signaling, which in turn impairs revascularization and thus muscle regeneration after ischemic injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    117
  • cDNA Data
    101
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170768 NCBI Gene Model | MGI Sequence Detail 82642 C57BL/6J ±  kb
    transcript NM_001177753 RefSeq | MGI Sequence Detail 5206 C57BL/6  
    polypeptide NP_001171224 RefSeq | MGI Sequence Detail 555 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      cDNA 101
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2442800
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 4
      Phenotypes 36
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:358010 Chen Y, et al., MiR-106a-5p targets PFKFB3 and improves sepsis through regulating macrophage pyroptosis and inflammatory response. J Biol Chem. 2024 Jun;300(6):107334
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory