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Bbc3 Gene Detail
Summary
  • Symbol
    Bbc3
  • Name
    BCL2 binding component 3
  • Synonyms
    PUMA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181667
    NCBI Gene: 170770
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16042318-16052130 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    313 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181667
 protein coding gene Chr7:16042307-16052130 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031707
 protein coding gene Chr7:14001344-14011802 (+)
A/J MGP_AJ_G0031679
 protein coding gene Chr7:13781429-13790030 (+)
AKR/J MGP_AKRJ_G0031604
 protein coding gene Chr7:14098506-14108912 (+)
BALB/cJ MGP_BALBcJ_G0031686
 protein coding gene Chr7:13882806-13891431 (+)
C3H/HeJ MGP_C3HHeJ_G0031408
 protein coding gene Chr7:14279508-14288022 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032152
 protein coding gene Chr7:14753010-14761597 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029231
 protein coding gene Chr7:15332995-15341618 (+)
CAST/EiJ MGP_CASTEiJ_G0030759
 protein coding gene Chr7:11041926-11050550 (+)
CBA/J MGP_CBAJ_G0031367
 protein coding gene Chr7:15212641-15221222 (+)
DBA/2J MGP_DBA2J_G0031523
 protein coding gene Chr7:13665046-13673584 (+)
FVB/NJ MGP_FVBNJ_G0031479
 protein coding gene Chr7:13559544-13568071 (+)
LP/J MGP_LPJ_G0031608
 protein coding gene Chr7:14261658-14272102 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031514
 protein coding gene Chr7:15178051-15186644 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032181
 protein coding gene Chr7:13876208-13884861 (+)
PWK/PhJ MGP_PWKPhJ_G0030483
 protein coding gene Chr7:11188119-11197203 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030310
 protein coding gene Chr7:8789521-8798134 (+)
WSB/EiJ MGP_WSBEiJ_G0030856
 protein coding gene Chr7:13923913-13934812 (+)



Homology
more
  • Human Ortholog
    BBC3, BCL2 binding component 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BBC3, BCL2 binding component 3
  • Synonyms
    JFY-1, JFY1, PUMA
  • Links
    NCBI Gene ID: 27113
    neXtProt AC: NX_Q96PG8, NX_Q9BXH1
    UniProt: Q96PG8, Q9BXH1

  • Chr Location
    19q13.32; chr19:47220822-47232860 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in apoptosis but otherwise are phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    43
  • cDNA Data
    18
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002083 Ensembl Gene Model | MGI Sequence Detail 9813 C57BL/6J ±  kb
    transcript ENSMUST00000002152 Ensembl | MGI Sequence Detail 1814 Not Applicable  
    polypeptide ENSMUSP00000002152 Ensembl | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 18
      Primer pair 11

      Microarray probesets 2
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 49
      Gene Ontology 18
      Phenotypes 113
    • Earliest
      J:76185 Yu J, et al., PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar;7(3):673-82
    • Latest
      J:347602 Shi Y, et al., Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects. Nat Commun. 2024 Apr 26;15(1):3301
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory