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Ormdl1 Gene Detail
Summary
  • Symbol
    Ormdl1
  • Name
    ORM1-like 1 (S. cerevisiae)
  • Synonyms
    C730042F17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181669
    NCBI Gene: 227102
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:53336254-53349404 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 26.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    462 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181669
 protein coding gene Chr1:53336254-53349468 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016017
 protein coding gene Chr1:52840672-52855640 (+)
A/J MGP_AJ_G0015999
 protein coding gene Chr1:51059788-51069877 (+)
AKR/J MGP_AKRJ_G0015955
 protein coding gene Chr1:52169437-52174289 (+)
BALB/cJ MGP_BALBcJ_G0015956
 protein coding gene Chr1:50877368-50894276 (+)
C3H/HeJ MGP_C3HHeJ_G0015788
 protein coding gene Chr1:52547751-52566014 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016407
 protein coding gene Chr1:55018206-55033328 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014117
 protein coding gene Chr1:40822470-40839113 (-)
CAST/EiJ MGP_CASTEiJ_G0015369
 protein coding gene Chr1:52036144-52049623 (+)
CBA/J MGP_CBAJ_G0015759
 protein coding gene Chr1:56525723-56536845 (+)
DBA/2J MGP_DBA2J_G0015860
 protein coding gene Chr1:50326445-50342594 (+)
FVB/NJ MGP_FVBNJ_G0015862
 protein coding gene Chr1:49783494-49797311 (+)
LP/J MGP_LPJ_G0015931
 protein coding gene Chr1:53263367-53276758 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015882
 protein coding gene Chr1:59596011-59610991 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016455
 protein coding gene Chr1:52276465-52292535 (+)
PWK/PhJ MGP_PWKPhJ_G0015155
 protein coding gene Chr1:50164174-50169006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014935
 protein coding gene Chr1:51944634-51950378 (+)
WSB/EiJ MGP_WSBEiJ_G0015432
 protein coding gene Chr1:52087529-52092381 (+)



Homology
more
  • Human Ortholog
    ORMDL1, ORMDL sphingolipid biosynthesis regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORMDL1, ORMDL sphingolipid biosynthesis regulator 1
  • Links
    NCBI Gene ID: 94101
    neXtProt AC: NX_Q9P0S3
    UniProt: Q9P0S3

  • Chr Location
    2q32.2; chr2:189763859-189784364 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    12 phenotype references
Homozygous null mice show normal intracellular calcium levels and granulation in mast cells upon activation and normal mast cell ceramide levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    70
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 227102 NCBI Gene Model | MGI Sequence Detail 13151 C57BL/6J ±  kb
transcript NM_145517 RefSeq | MGI Sequence Detail 1849 C57BL/6  
polypeptide Q921I0 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 70
    cDNA 70

    Microarray probesets 3
Other
Accession IDs
less
MGI:2443339
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:349249 Demkova L, et al., Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis. Front Immunol. 2024;15:1376629
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory