Mtnr1b MGI Mouse Gene Detail - MGI:2181726

Symbol

Mtnr1b
Name

melatonin receptor 1B
Synonyms

Mel1b, Mt2

Feature Type

protein coding gene
IDs

MGI:2181726
NCBI Gene: 244701
Alliance

gene page

Sequence Map

Chr9:15773910-15785852 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 5.15 cM
Mapping Data

1 experiment

SNPs within 2kb

519 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181726	protein coding gene	Chr9:15735824-15785852 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034369	protein coding gene	Chr9:12825512-12876993 (-)
A/J	MGP_AJ_G0034347	protein coding gene	Chr9:12758427-12808393 (-)
AKR/J	MGP_AKRJ_G0034275	protein coding gene	Chr9:12781952-12830830 (-)
BALB/cJ	MGP_BALBcJ_G0034341	protein coding gene	Chr9:12526071-12578298 (-)
C3H/HeJ	MGP_C3HHeJ_G0034052	protein coding gene	Chr9:13098813-13144898 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034863	protein coding gene	Chr9:13242268-13299911 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031801	protein coding gene	Chr9:12004649-12049184 (-)
CAST/EiJ	MGP_CASTEiJ_G0033379	protein coding gene	Chr9:12958440-13002433 (-)
CBA/J	MGP_CBAJ_G0034025	protein coding gene	Chr9:13863780-13923848 (-)
DBA/2J	MGP_DBA2J_G0034182	protein coding gene	Chr9:12606683-12658031 (-)
FVB/NJ	MGP_FVBNJ_G0034127	protein coding gene	Chr9:12188873-12239866 (-)
LP/J	MGP_LPJ_G0034268	protein coding gene	Chr9:12931979-13002866 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034171	protein coding gene	Chr9:14866076-14918086 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034882	protein coding gene	Chr9:12819018-12877960 (-)
PWK/PhJ	MGP_PWKPhJ_G0033085	protein coding gene	Chr9:12697160-12751564 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032920	protein coding gene	Chr9:12933825-12983541 (-)
WSB/EiJ	MGP_WSBEiJ_G0033495	protein coding gene	Chr9:12655037-12705406 (-)

Human Ortholog

MTNR1B, melatonin receptor 1B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTNR1B, melatonin receptor 1B
Synonyms

FGQTL2, MEL-1B-R, MT2
Links

HGNC:7464

NCBI Gene ID: 4544

neXtProt AC: NX_P49286

UniProt: P49286
Chr Location

11q14.3; chr11:92969651-92985066 (+) GRCh38

MGI Vertebrate Homology

Mtnr1b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MTNR1B
Gene Tree

Mtnr1b

Diseases

1 with human MTNR1B associations

				Human Disease	Mouse Models
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a knock-out allele are viable and fertile and display no obvious circadian phenotype.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

34
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtnr1b

ZFIN mtnr1ba

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS22841.1

Ensembl

ENSMUSG00000050901 (Evidence)
NCBI Gene

244701

			Length	Strain/Species	Flank
genomic	244701	NCBI Gene Model \| MGI Sequence Detail	11943	C57BL/6J	± kb
transcript	NM_145712	RefSeq \| MGI Sequence Detail	1244	C57BL/6
polypeptide	Q8CIQ6	UniProt \| EBI \| MGI Sequence Detail	364	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001610 melatonin receptor type 1B

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000025 Melatonin receptor family
GlyGen

Q8CIQ6 1 site

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All nucleic 5

cDNA 4

Primer pair 1

Microarray probesets 1

Summaries

All 64

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 36
Earliest

J:76848 Weaver DR, et al., Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov;10(11):1478-87
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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